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Pre-fusion structure of a human coronavirus spike protein

Author

Listed:
  • Robert N. Kirchdoerfer

    (The Scripps Research Institute)

  • Christopher A. Cottrell

    (The Scripps Research Institute)

  • Nianshuang Wang

    (Geisel School of Medicine at Dartmouth)

  • Jesper Pallesen

    (The Scripps Research Institute)

  • Hadi M. Yassine

    (Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases
    † Present address: Biomedical Research Center, Qatar University, QU-NRC, Zone 5, Room D130, Doha, Qatar.)

  • Hannah L. Turner

    (The Scripps Research Institute)

  • Kizzmekia S. Corbett

    (Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases)

  • Barney S. Graham

    (Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases)

  • Jason S. McLellan

    (Geisel School of Medicine at Dartmouth)

  • Andrew B. Ward

    (The Scripps Research Institute)

Abstract

A 4.0 Å resolution cryo-electron microscopy structure of the pre-fusion form of the trimeric spike from the human coronavirus HKU1 provides insight into how the spike protein mediates host-cell attachment and membrane fusion.

Suggested Citation

  • Robert N. Kirchdoerfer & Christopher A. Cottrell & Nianshuang Wang & Jesper Pallesen & Hadi M. Yassine & Hannah L. Turner & Kizzmekia S. Corbett & Barney S. Graham & Jason S. McLellan & Andrew B. Ward, 2016. "Pre-fusion structure of a human coronavirus spike protein," Nature, Nature, vol. 531(7592), pages 118-121, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7592:d:10.1038_nature17200
    DOI: 10.1038/nature17200
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    Cited by:

    1. Tugba Taskin Tok & Sivakumar J T Gowder, 2020. "An Updated Review on Covid-19 with Special Reference to Structural Elucidation and Functional Properties," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(4), pages 24345-24351, November.
    2. Massimo Florio, 2022. "To what extent patents for Covid-19 mRNA vaccines are based on public research and taxpayers’ funding? A case study on the privatization of knowledge [For Billion-Dollar COVID Vaccines, Basic Gover," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 31(5), pages 1137-1151.
    3. Shahzar Khan & Abdullah & Shah Faisal & Shah Faisal & Hazrat Usman & Rimsha Zainab & Faqeer Taj & Rahma Amrani & Muhammad Tayyeb, 2020. "COVID-19 - A brief overview on the role of Vitamins specifically Vitamin C as immune modulators and in prevention and treatment of SARS-Cov-2 infections," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 28(3), pages 21580-21586, June.
    4. Massimo FLORIO, 2021. "Patents for Covid-19 vaccines are based on public research: a case study on the privatization of knowledge," CIRIEC Working Papers 2103, CIRIEC - Université de Liège.
    5. Timothy J. C. Tan & Zongjun Mou & Ruipeng Lei & Wenhao O. Ouyang & Meng Yuan & Ge Song & Raiees Andrabi & Ian A. Wilson & Collin Kieffer & Xinghong Dai & Kenneth A. Matreyek & Nicholas C. Wu, 2023. "High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Geoffrey B. Hutchinson & Olubukola M. Abiona & Cynthia T. Ziwawo & Anne P. Werner & Daniel Ellis & Yaroslav Tsybovsky & Sarah R. Leist & Charis Palandjian & Ande West & Ethan J. Fritch & Nianshuang Wa, 2023. "Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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