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Telomerase activation by genomic rearrangements in high-risk neuroblastoma

Author

Listed:
  • Martin Peifer

    (Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
    Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Falk Hertwig

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Frederik Roels

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Daniel Dreidax

    (German Cancer Research Center)

  • Moritz Gartlgruber

    (German Cancer Research Center)

  • Roopika Menon

    (Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn
    NEO New Oncology AG)

  • Andrea Krämer

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Justin L. Roncaioli

    (University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center)

  • Frederik Sand

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Johannes M. Heuckmann

    (NEO New Oncology AG)

  • Fakhera Ikram

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
    Cologne Center for Genomics, University of Cologne)

  • Rene Schmidt

    (Institute of Biostatistics and Clinical Research, University of Münster)

  • Sandra Ackermann

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Anne Engesser

    (University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Yvonne Kahlert

    (University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Wenzel Vogel

    (Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn)

  • Janine Altmüller

    (Cologne Center for Genomics, University of Cologne)

  • Peter Nürnberg

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    Cologne Center for Genomics, University of Cologne
    Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne)

  • Jean Thierry-Mieg

    (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health)

  • Danielle Thierry-Mieg

    (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health)

  • Aruljothi Mariappan

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Stefanie Heynck

    (NEO New Oncology AG)

  • Erika Mariotti

    (NEO New Oncology AG)

  • Kai-Oliver Henrich

    (German Cancer Research Center)

  • Christian Gloeckner

    (NEO New Oncology AG)

  • Graziella Bosco

    (Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne)

  • Ivo Leuschner

    (University of Kiel)

  • Michal R. Schweiger

    (Functional Epigenomics, University of Cologne)

  • Larissa Savelyeva

    (German Cancer Research Center)

  • Simon C. Watkins

    (Center for Biologic Imaging, University of Pittsburgh)

  • Chunxuan Shao

    (German Cancer Research Center (DKFZ))

  • Emma Bell

    (German Cancer Research Center)

  • Thomas Höfer

    (German Cancer Research Center (DKFZ))

  • Viktor Achter

    (Computing Center, University of Cologne)

  • Ulrich Lang

    (Computing Center, University of Cologne
    University of Cologne)

  • Jessica Theissen

    (University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Ruth Volland

    (University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Maral Saadati

    (German Cancer Research Center (DKFZ))

  • Angelika Eggert

    (Charité University Medical Center Berlin)

  • Bram de Wilde

    (Center for Medical Genetics, Ghent University)

  • Frank Berthold

    (University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Zhiyu Peng

    (BGI-Shenzhen, Bei Shan Industrial Zone, Yantian District)

  • Chen Zhao

    (Center for Pharmacogenomics and Fudan-Zhangjiang Center for Clinical Genomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Pharmacy and School of Life Sciences, Fudan University)

  • Leming Shi

    (Center for Pharmacogenomics and Fudan-Zhangjiang Center for Clinical Genomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Pharmacy and School of Life Sciences, Fudan University)

  • Monika Ortmann

    (University of Cologne)

  • Reinhard Büttner

    (University of Cologne)

  • Sven Perner

    (Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn)

  • Barbara Hero

    (University Children’s Hospital of Cologne, Medical Faculty, University of Cologne)

  • Alexander Schramm

    (University Children’s Hospital)

  • Johannes H. Schulte

    (Charité University Medical Center Berlin
    German Cancer Consortium (DKTK)
    German Cancer Research Center (DKFZ))

  • Carl Herrmann

    (Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg
    Bioquant Center, University of Heidelberg
    German Cancer Research Center (DKFZ))

  • Roderick J. O’Sullivan

    (University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center)

  • Frank Westermann

    (German Cancer Research Center)

  • Roman K. Thomas

    (Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne
    University of Cologne)

  • Matthias Fischer

    (Center for Molecular Medicine Cologne (CMMC), University of Cologne
    University Children’s Hospital of Cologne, Medical Faculty, University of Cologne
    Max Planck Institute for Metabolism Research)

Abstract

Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT, by MYCN amplification, or ATRX mutations—is a hallmark of high-risk neuroblastomas.

Suggested Citation

  • Martin Peifer & Falk Hertwig & Frederik Roels & Daniel Dreidax & Moritz Gartlgruber & Roopika Menon & Andrea Krämer & Justin L. Roncaioli & Frederik Sand & Johannes M. Heuckmann & Fakhera Ikram & Rene, 2015. "Telomerase activation by genomic rearrangements in high-risk neuroblastoma," Nature, Nature, vol. 526(7575), pages 700-704, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7575:d:10.1038_nature14980
    DOI: 10.1038/nature14980
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    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
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    Cited by:

    1. Francesc Muyas & Manuel José Gómez Rodriguez & Rita Cascão & Angela Afonso & Carolin M. Sauer & Claudia C. Faria & Isidro Cortés-Ciriano & Ignacio Flores, 2024. "The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Karin Schmelz & Joern Toedling & Matt Huska & Maja C. Cwikla & Louisa-Marie Kruetzfeldt & Jutta Proba & Peter F. Ambros & Inge M. Ambros & Sengül Boral & Marco Lodrini & Celine Y. Chen & Martin Burker, 2021. "Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Cécile Thirant & Agathe Peltier & Simon Durand & Amira Kramdi & Caroline Louis-Brennetot & Cécile Pierre-Eugène & Margot Gautier & Ana Costa & Amandine Grelier & Sakina Zaïdi & Nadège Gruel & Irène Ji, 2023. "Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Benjamin A. Nacev & Francisco Sanchez-Vega & Shaleigh A. Smith & Cristina R. Antonescu & Evan Rosenbaum & Hongyu Shi & Cerise Tang & Nicholas D. Socci & Satshil Rana & Rodrigo Gularte-Mérida & Ahmet Z, 2022. "Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Steffen Fuchs & Clara Danßmann & Filippos Klironomos & Annika Winkler & Jörg Fallmann & Louisa-Marie Kruetzfeldt & Annabell Szymansky & Julian Naderi & Stephan H. Bernhart & Laura Grunewald & Konstant, 2023. "Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Irfete S. Fetahu & Wolfgang Esser-Skala & Rohit Dnyansagar & Samuel Sindelar & Fikret Rifatbegovic & Andrea Bileck & Lukas Skos & Eva Bozsaky & Daria Lazic & Lisa Shaw & Marcus Tötzl & Dora Tarlungean, 2023. "Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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