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The evolutionary history of lethal metastatic prostate cancer

Author

Listed:
  • Gunes Gundem

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Peter Van Loo

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    KU Leuven
    Cancer Research UK London Research Institute)

  • Barbara Kremeyer

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Ludmil B. Alexandrov

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jose M. C. Tubio

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Elli Papaemmanuil

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Daniel S. Brewer

    (University of East Anglia
    The Genome Analysis Centre)

  • Heini M. L. Kallio

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

  • Gunilla Högnäs

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

  • Matti Annala

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

  • Kati Kivinummi

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

  • Victoria Goody

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Calli Latimer

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah O'Meara

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kevin J. Dawson

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • William Isaacs

    (The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine)

  • Michael R. Emmert-Buck

    (Laboratory of Pathology, National Cancer Institute, National Institutes of Health
    † Present address: Avoneaux Medical Institute, Oxford, Maryland 21654, USA.)

  • Matti Nykter

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

  • Christopher Foster

    (University of Liverpool and HCA Pathology Laboratories)

  • Zsofia Kote-Jarai

    (The Institute Of Cancer Research)

  • Douglas Easton

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Hayley C. Whitaker

    (Uro-oncology Research Group, Cancer Research UK Cambridge Institute)

  • David E. Neal

    (Uro-oncology Research Group, Cancer Research UK Cambridge Institute
    University of Cambridge, Addenbrooke's Hospital)

  • Colin S. Cooper

    (University of East Anglia
    The Institute Of Cancer Research)

  • Rosalind A. Eeles

    (The Institute Of Cancer Research
    Royal Marsden NHS Foundation Trust
    and ,)

  • Tapio Visakorpi

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

  • Peter J. Campbell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Ultan McDermott

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • David C. Wedge

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • G. Steven Bova

    (Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital)

Abstract

The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees behind the development and spread of these cancers; an important observation was that metastases could be re-seeded multiple times, and spread from one tumour to another was frequently seen.

Suggested Citation

  • Gunes Gundem & Peter Van Loo & Barbara Kremeyer & Ludmil B. Alexandrov & Jose M. C. Tubio & Elli Papaemmanuil & Daniel S. Brewer & Heini M. L. Kallio & Gunilla Högnäs & Matti Annala & Kati Kivinummi &, 2015. "The evolutionary history of lethal metastatic prostate cancer," Nature, Nature, vol. 520(7547), pages 353-357, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7547:d:10.1038_nature14347
    DOI: 10.1038/nature14347
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    Citations

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    Cited by:

    1. Zicheng Wang & Yunong Xia & Lauren Mills & Athanasios N. Nikolakopoulos & Nicole Maeser & Scott M. Dehm & Jason M. Sheltzer & Ruping Sun, 2024. "Evolving copy number gains promote tumor expansion and bolster mutational diversification," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Zura Kakushadze & Willie Yu, 2016. "Factor Models for Cancer Signatures," Papers 1604.08743, arXiv.org, revised Jan 2017.
    3. Udit Singhal & Srinivas Nallandhighal & Jeffrey J. Tosoian & Kevin Hu & Trinh M. Pham & Judith Stangl-Kremser & Chia-Jen Liu & Razeen Karim & Komal R. Plouffe & Todd M. Morgan & Marcin Cieslik & Rober, 2024. "Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    4. Zura Kakushadze & Willie Yu, 2017. "*K-means and Cluster Models for Cancer Signatures," Papers 1703.00703, arXiv.org, revised Jul 2017.
    5. Huiqiang Cai & Bin Zhang & Johanne Ahrenfeldt & Justin V. Joseph & Maria Riedel & Zongliang Gao & Sofie K. Thomsen & Ditte S. Christensen & Rasmus O. Bak & Henrik Hager & Mikkel H. Vendelbo & Xin Gao , 2024. "CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    6. Kakushadze, Zura & Yu, Willie, 2016. "Factor models for cancer signatures," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 462(C), pages 527-559.
    7. Naser Ansari-Pour & Yonglan Zheng & Toshio F. Yoshimatsu & Ayodele Sanni & Mustapha Ajani & Jean-Baptiste Reynier & Avraam Tapinos & Jason J. Pitt & Stefan Dentro & Anna Woodard & Padma Sheila Rajagop, 2021. "Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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