IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v515y2014i7528d10.1038_nature14011.html
   My bibliography  Save this article

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Author

Listed:
  • Roy S. Herbst

    (Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA)

  • Jean-Charles Soria

    (Gustave Roussy South-Paris University, 114 Rue Edouard Vaillant, 94805 Villefuij, Cedex, France)

  • Marcin Kowanetz

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Gregg D. Fine

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Omid Hamid

    (The Angeles Clinic and Research Institute, 11818 Wilshire Blvd)

  • Michael S. Gordon

    (Pinnacle Oncology Hematology, 9055 E Del Camino Dr 100)

  • Jeffery A. Sosman

    (Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue)

  • David F. McDermott

    (Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, Massachusetts 02215, USA)

  • John D. Powderly

    (Carolina BioOncology Institute, 9801 W. Kincey Ave, Suite 145, Huntersville, North Carolina 28078, USA)

  • Scott N. Gettinger

    (Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA)

  • Holbrook E. K. Kohrt

    (Stanford University, CCSR Bldg Room 1110)

  • Leora Horn

    (Vanderbilt-Ingram Cancer Center, 1301 Medical Center Dr, Suite 1710, Nashville, Tennessee 37212, USA)

  • Donald P. Lawrence

    (Massachusetts General Hospital, 55 Fruit Street, YAW 9E, Boston, Massachusetts 02114, USA)

  • Sandra Rost

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Maya Leabman

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Yuanyuan Xiao

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ahmad Mokatrin

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Hartmut Koeppen

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Priti S. Hegde

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ira Mellman

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Daniel S. Chen

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • F. Stephen Hodi

    (Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue)

Abstract

Clinical and correlative biomarker results from a phase 1 clinical trial in patients with different solid tumours are presented; the findings indicate that PD-L1 expression on tumour-infiltrating immune cells is associated with clinical response to MPDL3280A (anti-PD-L1).

Suggested Citation

  • Roy S. Herbst & Jean-Charles Soria & Marcin Kowanetz & Gregg D. Fine & Omid Hamid & Michael S. Gordon & Jeffery A. Sosman & David F. McDermott & John D. Powderly & Scott N. Gettinger & Holbrook E. K. , 2014. "Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients," Nature, Nature, vol. 515(7528), pages 563-567, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature14011
    DOI: 10.1038/nature14011
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14011
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14011?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature14011. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.