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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Author

Listed:
  • Roy S. Herbst

    (Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA)

  • Jean-Charles Soria

    (Gustave Roussy South-Paris University, 114 Rue Edouard Vaillant, 94805 Villefuij, Cedex, France)

  • Marcin Kowanetz

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Gregg D. Fine

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Omid Hamid

    (The Angeles Clinic and Research Institute, 11818 Wilshire Blvd)

  • Michael S. Gordon

    (Pinnacle Oncology Hematology, 9055 E Del Camino Dr 100)

  • Jeffery A. Sosman

    (Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue)

  • David F. McDermott

    (Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, Massachusetts 02215, USA)

  • John D. Powderly

    (Carolina BioOncology Institute, 9801 W. Kincey Ave, Suite 145, Huntersville, North Carolina 28078, USA)

  • Scott N. Gettinger

    (Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA)

  • Holbrook E. K. Kohrt

    (Stanford University, CCSR Bldg Room 1110)

  • Leora Horn

    (Vanderbilt-Ingram Cancer Center, 1301 Medical Center Dr, Suite 1710, Nashville, Tennessee 37212, USA)

  • Donald P. Lawrence

    (Massachusetts General Hospital, 55 Fruit Street, YAW 9E, Boston, Massachusetts 02114, USA)

  • Sandra Rost

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Maya Leabman

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Yuanyuan Xiao

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ahmad Mokatrin

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Hartmut Koeppen

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Priti S. Hegde

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ira Mellman

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Daniel S. Chen

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • F. Stephen Hodi

    (Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue)

Abstract

Clinical and correlative biomarker results from a phase 1 clinical trial in patients with different solid tumours are presented; the findings indicate that PD-L1 expression on tumour-infiltrating immune cells is associated with clinical response to MPDL3280A (anti-PD-L1).

Suggested Citation

  • Roy S. Herbst & Jean-Charles Soria & Marcin Kowanetz & Gregg D. Fine & Omid Hamid & Michael S. Gordon & Jeffery A. Sosman & David F. McDermott & John D. Powderly & Scott N. Gettinger & Holbrook E. K. , 2014. "Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients," Nature, Nature, vol. 515(7528), pages 563-567, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature14011
    DOI: 10.1038/nature14011
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