IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v510y2014i7503d10.1038_nature13478.html
   My bibliography  Save this article

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Author

Listed:
  • Rachel J. Perry

    (Yale University School of Medicine)

  • Varman T. Samuel

    (Yale University School of Medicine
    VA Connecticut Healthcare System West Haven)

  • Kitt F. Petersen

    (Yale University School of Medicine
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen)

  • Gerald I. Shulman

    (Yale University School of Medicine
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
    Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University School of Medicine)

Abstract

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cε in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

Suggested Citation

  • Rachel J. Perry & Varman T. Samuel & Kitt F. Petersen & Gerald I. Shulman, 2014. "The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes," Nature, Nature, vol. 510(7503), pages 84-91, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13478
    DOI: 10.1038/nature13478
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13478
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13478?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Oriol Juanola & Sebastián Martínez-López & Rubén Francés & Isabel Gómez-Hurtado, 2021. "Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors," IJERPH, MDPI, vol. 18(10), pages 1-24, May.
    2. Anna Worthmann & Julius Ridder & Sharlaine Y. L. Piel & Ioannis Evangelakos & Melina Musfeldt & Hannah Voß & Marie O’Farrell & Alexander W. Fischer & Sangeeta Adak & Monica Sundd & Hasibullah Siffeti , 2024. "Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:510:y:2014:i:7503:d:10.1038_nature13478. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.