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Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

Author

Listed:
  • Theresa Alenghat

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    School of Veterinary Medicine, University of Pennsylvania)

  • Lisa C. Osborne

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Steven A. Saenz

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Dmytro Kobuley

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Carly G. K. Ziegler

    (Perelman School of Medicine, University of Pennsylvania)

  • Shannon E. Mullican

    (Diabetes, and Metabolism, University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania)

  • Inchan Choi

    (The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Stephanie Grunberg

    (Perelman School of Medicine, University of Pennsylvania)

  • Rohini Sinha

    (Perelman School of Medicine, University of Pennsylvania)

  • Meghan Wynosky-Dolfi

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    School of Veterinary Medicine, University of Pennsylvania)

  • Annelise Snyder

    (School of Veterinary Medicine, University of Pennsylvania)

  • Paul R. Giacomin

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Karen L. Joyce

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Tram B. Hoang

    (Perelman School of Medicine, University of Pennsylvania)

  • Meenakshi Bewtra

    (Perelman School of Medicine, University of Pennsylvania
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania)

  • Igor E. Brodsky

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    School of Veterinary Medicine, University of Pennsylvania)

  • Gregory F. Sonnenberg

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Frederic D. Bushman

    (Perelman School of Medicine, University of Pennsylvania)

  • Kyoung-Jae Won

    (The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Mitchell A. Lazar

    (Diabetes, and Metabolism, University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • David Artis

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    School of Veterinary Medicine, University of Pennsylvania)

Abstract

This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene expression and intestinal homeostasis; IEC-specific HDAC3 deficiency gives rise to Paneth cell abnormalities, impaired intestinal barrier function, and increased DSS-induced intestinal inflammation in commensal-bacteria-containing, but not germ-free, mice.

Suggested Citation

  • Theresa Alenghat & Lisa C. Osborne & Steven A. Saenz & Dmytro Kobuley & Carly G. K. Ziegler & Shannon E. Mullican & Inchan Choi & Stephanie Grunberg & Rohini Sinha & Meghan Wynosky-Dolfi & Annelise Sn, 2013. "Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis," Nature, Nature, vol. 504(7478), pages 153-157, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12687
    DOI: 10.1038/nature12687
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    Cited by:

    1. Marjolein Heddes & Baraa Altaha & Yunhui Niu & Sandra Reitmeier & Karin Kleigrewe & Dirk Haller & Silke Kiessling, 2022. "The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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