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Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

Author

Listed:
  • Masashi Shingai

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Yoshiaki Nishimura

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Florian Klein

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Hugo Mouquet

    (Laboratory of Humoral Response to Pathogens, Institut Pasteur, 75015 Paris, France)

  • Olivia K. Donau

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Ronald Plishka

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Alicia Buckler-White

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Michael Seaman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle)

  • Michael Piatak

    (AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA)

  • Dimiter Dimitrov

    (Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Center for Cancer Research, National Cancer Institute, National Institutes of Health
    Howard Hughes Medical Institute, The Rockefeller University)

  • Malcolm A. Martin

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

A new generation of broad and potent anti-HIV-1 monoclonal antibodies has recently been isolated; co-administration of two such antibodies is shown here to result in rapid and potent suppression of plasma viraemia in five chronically SHIV-infected macaques that lasts for several weeks.

Suggested Citation

  • Masashi Shingai & Yoshiaki Nishimura & Florian Klein & Hugo Mouquet & Olivia K. Donau & Ronald Plishka & Alicia Buckler-White & Michael Seaman & Michael Piatak & Jeffrey D. Lifson & Dimiter Dimitrov &, 2013. "Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia," Nature, Nature, vol. 503(7475), pages 277-280, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7475:d:10.1038_nature12746
    DOI: 10.1038/nature12746
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    Citations

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    Cited by:

    1. Craig A Magaret & David C Benkeser & Brian D Williamson & Bhavesh R Borate & Lindsay N Carpp & Ivelin S Georgiev & Ian Setliff & Adam S Dingens & Noah Simon & Marco Carone & Christopher Simpkins & Dav, 2019. "Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features," PLOS Computational Biology, Public Library of Science, vol. 15(4), pages 1-35, April.
    2. Jérémy Dufloo & Cyril Planchais & Stéphane Frémont & Valérie Lorin & Florence Guivel-Benhassine & Karl Stefic & Nicoletta Casartelli & Arnaud Echard & Philippe Roingeard & Hugo Mouquet & Olivier Schwa, 2022. "Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Lucia Reh & Carsten Magnus & Merle Schanz & Jacqueline Weber & Therese Uhr & Peter Rusert & Alexandra Trkola, 2015. "Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent," PLOS Pathogens, Public Library of Science, vol. 11(7), pages 1-34, July.
    4. Karunasinee Suphaphiphat & Delphine Desjardins & Valérie Lorin & Nastasia Dimant & Kawthar Bouchemal & Laetitia Bossevot & Maxence Galpin-Lebreau & Nathalie Dereuddre-Bosquet & Hugo Mouquet & Roger Gr, 2023. "Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Nicole A Doria-Rose & Han R Altae-Tran & Ryan S Roark & Stephen D Schmidt & Matthew S Sutton & Mark K Louder & Gwo-Yu Chuang & Robert T Bailer & Valerie Cortez & Rui Kong & Krisha McKee & Sijy O’Dell , 2017. "Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting," PLOS Pathogens, Public Library of Science, vol. 13(1), pages 1-29, January.

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