IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v502y2013i7470d10.1038_nature12606.html
   My bibliography  Save this article

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

Author

Listed:
  • Zaiming Tang

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Biophysics and Structural Biology, University of California
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University)

  • Mary Grace Lin

    (Biophysics and Structural Biology, University of California)

  • Timothy Richard Stowe

    (Stanford University)

  • She Chen

    (National Institute of Biological Sciences)

  • Muyuan Zhu

    (State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University)

  • Tim Stearns

    (Stanford University)

  • Brunella Franco

    (Medical Genetics Services, Federico II University, Via Pietro Castellino 111, Naples, Italy
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, Naples, Italy)

  • Qing Zhong

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Biophysics and Structural Biology, University of California)

Abstract

The primary cilium is a microtubule-based organelle that functions in sensory and signal transduction; the authors demonstrate here that autophagic degradation of the oral-facial-digital syndrome 1 (OFD1) protein at centriolar satellites promotes primary cilium biogenesis, and that autophagy modulation might provide a novel means of ciliopathy treatment.

Suggested Citation

  • Zaiming Tang & Mary Grace Lin & Timothy Richard Stowe & She Chen & Muyuan Zhu & Tim Stearns & Brunella Franco & Qing Zhong, 2013. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites," Nature, Nature, vol. 502(7470), pages 254-257, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12606
    DOI: 10.1038/nature12606
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12606
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12606?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Aurore Claude-Taupin & Pierre Isnard & Alessia Bagattin & Nicolas Kuperwasser & Federica Roccio & Biagina Ruscica & Nicolas Goudin & Meriem Garfa-Traoré & Alice Regnier & Lisa Turinsky & Martine Burti, 2023. "The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Muqing Cao & Xiaoxiao Zou & Chaoyi Li & Zaisheng Lin & Ni Wang & Zhongju Zou & Youqiong Ye & Joachim Seemann & Beth Levine & Zaiming Tang & Qing Zhong, 2023. "An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12606. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.