IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v498y2013i7455d10.1038_nature12216.html
   My bibliography  Save this article

Severe malaria is associated with parasite binding to endothelial protein C receptor

Author

Listed:
  • Louise Turner

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Thomas Lavstsen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Sanne S. Berger

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Christian W. Wang

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Jens E. V. Petersen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Marion Avril

    (Seattle Biomedical Research Institute)

  • Andrew J. Brazier

    (Seattle Biomedical Research Institute)

  • Jim Freeth

    (Retrogenix, Crown House, Bingswood Estate, Whaley Bridge, High Peak SK23 7LY, UK)

  • Jakob S. Jespersen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Morten A. Nielsen

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

  • Pamela Magistrado

    (National Institute of Medical Research, Tanga Centre, Tanga, Tanzania)

  • John Lusingu

    (National Institute of Medical Research, Tanga Centre, Tanga, Tanzania)

  • Joseph D. Smith

    (Seattle Biomedical Research Institute
    University of Washington)

  • Matthew K. Higgins

    (University of Oxford, South Parks Road, Oxford OX1 3QU, UK)

  • Thor G. Theander

    (Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark)

Abstract

Endothelial protein C receptor is shown to be the receptor for Plasmodium falciparum erythrocyte membrane protein 1 variants associated with severe malaria.

Suggested Citation

  • Louise Turner & Thomas Lavstsen & Sanne S. Berger & Christian W. Wang & Jens E. V. Petersen & Marion Avril & Andrew J. Brazier & Jim Freeth & Jakob S. Jespersen & Morten A. Nielsen & Pamela Magistrado, 2013. "Severe malaria is associated with parasite binding to endothelial protein C receptor," Nature, Nature, vol. 498(7455), pages 502-505, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12216
    DOI: 10.1038/nature12216
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12216
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12216?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gerry Q Tonkin-Hill & Leily Trianty & Rintis Noviyanti & Hanh H T Nguyen & Boni F Sebayang & Daniel A Lampah & Jutta Marfurt & Simon A Cobbold & Janavi S Rambhatla & Malcolm J McConville & Stephen J R, 2018. "The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes," PLOS Biology, Public Library of Science, vol. 16(3), pages 1-40, March.
    2. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12216. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.