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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Author

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  • Markus Kleinewietfeld

    (Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
    Broad Institute of MIT and Harvard, 7 Cambridge Center)

  • Arndt Manzel

    (University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150)

  • Jens Titze

    (Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
    University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany)

  • Heda Kvakan

    (Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
    Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany)

  • Nir Yosef

    (Broad Institute of MIT and Harvard, 7 Cambridge Center)

  • Ralf A. Linker

    (University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany)

  • Dominik N. Muller

    (Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
    Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany)

  • David A. Hafler

    (Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
    Broad Institute of MIT and Harvard, 7 Cambridge Center)

Abstract

Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells.

Suggested Citation

  • Markus Kleinewietfeld & Arndt Manzel & Jens Titze & Heda Kvakan & Nir Yosef & Ralf A. Linker & Dominik N. Muller & David A. Hafler, 2013. "Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells," Nature, Nature, vol. 496(7446), pages 518-522, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature11868
    DOI: 10.1038/nature11868
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    Cited by:

    1. Robert Haas & Joanne Smith & Vidalba Rocher-Ros & Suchita Nadkarni & Trinidad Montero-Melendez & Fulvio D’Acquisto & Elliot J Bland & Michele Bombardieri & Costantino Pitzalis & Mauro Perretti & Feder, 2015. "Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions," PLOS Biology, Public Library of Science, vol. 13(7), pages 1-24, July.

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