IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v495y2013i7440d10.1038_nature12005.html
   My bibliography  Save this article

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

Author

Listed:
  • V. Stalin Raj

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Huihui Mou

    (Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands)

  • Saskia L. Smits

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Viroclinics Biosciences BV, 3029 AK Rotterdam, The Netherlands)

  • Dick H. W. Dekkers

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Marcel A. Müller

    (Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany)

  • Ronald Dijkman

    (Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland)

  • Doreen Muth

    (Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany)

  • Jeroen A. A. Demmers

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Ali Zaki

    (Virology Laboratory, Dr Soliman Fakeeh Hospital)

  • Ron A. M. Fouchier

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Volker Thiel

    (Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    Vetsuisse Faculty, University of Zürich, 8057 Zürich, Switzerland)

  • Christian Drosten

    (Institute of Virology, University of Bonn Medical Centre, 53105 Bonn, Germany)

  • Peter J. M. Rottier

    (Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands)

  • Albert D. M. E. Osterhaus

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

  • Berend Jan Bosch

    (Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands)

  • Bart L. Haagmans

    (Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands)

Abstract

Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.

Suggested Citation

  • V. Stalin Raj & Huihui Mou & Saskia L. Smits & Dick H. W. Dekkers & Marcel A. Müller & Ronald Dijkman & Doreen Muth & Jeroen A. A. Demmers & Ali Zaki & Ron A. M. Fouchier & Volker Thiel & Christian Dr, 2013. "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC," Nature, Nature, vol. 495(7440), pages 251-254, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature12005
    DOI: 10.1038/nature12005
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12005
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12005?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Milad Haghani & Pegah Varamini, 2021. "Temporal evolution, most influential studies and sleeping beauties of the coronavirus literature," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(8), pages 7005-7050, August.
    2. Hossein Hozhabri & Francesca Piceci Sparascio & Hamidreza Sohrabi & Leila Mousavifar & René Roy & Daniela Scribano & Alessandro De Luca & Cecilia Ambrosi & Meysam Sarshar, 2020. "The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting," IJERPH, MDPI, vol. 17(16), pages 1-35, August.
    3. Weiwei Ji & Qi Peng & Xueqiong Fang & Zehou Li & Yaxin Li & Cunfa Xu & Shuqing Zhao & Jizong Li & Rong Chen & Guoxiang Mo & Zhanyong Wei & Ying Xu & Bin Li & Shuijun Zhang, 2022. "Structures of a deltacoronavirus spike protein bound to porcine and human receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Tuersunjiang Keyoumu & Wanbiao Ma & Ke Guo, 2023. "Global Stability of a MERS-CoV Infection Model with CTL Immune Response and Intracellular Delay," Mathematics, MDPI, vol. 11(4), pages 1-26, February.
    5. Shubhadeep Roychoudhury & Anandan Das & Pallav Sengupta & Sulagna Dutta & Shatabhisha Roychoudhury & Arun Paul Choudhury & A. B. Fuzayel Ahmed & Saumendra Bhattacharjee & Petr Slama, 2020. "Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives," IJERPH, MDPI, vol. 17(24), pages 1-39, December.
    6. Maria Mirabelli & Eusebio Chiefari & Luigi Puccio & Daniela Patrizia Foti & Antonio Brunetti, 2020. "Potential Benefits and Harms of Novel Antidiabetic Drugs During COVID-19 Crisis," IJERPH, MDPI, vol. 17(10), pages 1-12, May.
    7. Yan Yang & Zixin Cai & Jingjing Zhang, 2021. "DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-10, May.
    8. Mohamed A. Farrag & Haitham M. Amer & Rauf Bhat & Maaweya E. Hamed & Ibrahim M. Aziz & Ayman Mubarak & Turki M Dawoud & Sami G Almalki & Fayez Alghofaili & Ahmad K. Alnemare & Raid Saleem Al-Baradi & , 2021. "SARS-CoV-2: An Overview of Virus Genetics, Transmission, and Immunopathogenesis," IJERPH, MDPI, vol. 18(12), pages 1-14, June.
    9. Magen E. Francis & Ethan B. Jansen & Anthony Yourkowski & Alaa Selim & Cynthia L. Swan & Brian K. MacPhee & Brittany Thivierge & Rachelle Buchanan & Kerry J. Lavender & Joseph Darbellay & Matthew B. R, 2023. "Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    10. Muhammad Azher Hassan & Tariq Mehmood & Ehtisham Lodhi & Muhammad Bilal & Afzal Ahmed Dar & Junjie Liu, 2022. "Lockdown Amid COVID-19 Ascendancy over Ambient Particulate Matter Pollution Anomaly," IJERPH, MDPI, vol. 19(20), pages 1-31, October.
    11. Chunyan Wang & Emma L. Hesketh & Tatiana M. Shamorkina & Wentao Li & Peter J. Franken & Dubravka Drabek & Rien Haperen & Sarah Townend & Frank J. M. Kuppeveld & Frank Grosveld & Neil A. Ranson & Joost, 2022. "Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    12. Luo-Yuan Xia & Zhen-Fei Wang & Xiao-Ming Cui & Yuan-Guo Li & Run-Ze Ye & Dai-Yun Zhu & Fang-Xu Li & Jie Zhang & Wen-Hao Wang & Ming-Zhu Zhang & Wan-Ying Gao & Lian-Feng Li & Teng-Cheng Que & Tie-Cheng, 2024. "Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature12005. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.