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A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

Author

Listed:
  • Kimberley D. Seed

    (Tufts University School of Medicine)

  • David W. Lazinski

    (Tufts University School of Medicine)

  • Stephen B. Calderwood

    (Massachusetts General Hospital
    Harvard Medical School)

  • Andrew Camilli

    (Tufts University School of Medicine)

Abstract

CRISPR/Cas systems are bacterial adaptive immune systems that provide sequence-specific protection from invading nucleic acids, including from bacteriophages; in a notable reverse a vibriophage-encoded CRISPR/Cas system, used to disable a bacteriophage inhibitory chromosomal island in Vibrio cholerae, is identified.

Suggested Citation

  • Kimberley D. Seed & David W. Lazinski & Stephen B. Calderwood & Andrew Camilli, 2013. "A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity," Nature, Nature, vol. 494(7438), pages 489-491, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7438:d:10.1038_nature11927
    DOI: 10.1038/nature11927
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    Cited by:

    1. Friederike S Rossmann & Tomas Racek & Dominique Wobser & Jacek Puchalka & Elaine M Rabener & Matthias Reiger & Antoni P A Hendrickx & Ann-Kristin Diederich & Kirsten Jung & Christoph Klein & Johannes , 2015. "Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing," PLOS Pathogens, Public Library of Science, vol. 11(2), pages 1-17, February.

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