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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

Author

Listed:
  • Florian Klein

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Ariel Halper-Stromberg

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Joshua A. Horwitz

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Henning Gruell

    (Laboratory of Molecular Immunology, The Rockefeller University
    Medizinische Fakultät, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany)

  • Johannes F. Scheid

    (Laboratory of Molecular Immunology, The Rockefeller University
    Charité Universitätsmedizin)

  • Stylianos Bournazos

    (Laboratory of Molecular Genetics and Immunology, The Rockefeller University)

  • Hugo Mouquet

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Linda A. Spatz

    (Laboratory of Molecular Immunology, The Rockefeller University
    Sophie Davis School of Biomedical Education, The City College of New York)

  • Ron Diskin

    (California Institute of Technology)

  • Alexander Abadir

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Trinity Zang

    (Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University)

  • Marcus Dorner

    (Laboratory of Virology and Infectious Diseases, The Rockefeller University)

  • Eva Billerbeck

    (Laboratory of Virology and Infectious Diseases, The Rockefeller University)

  • Rachael N. Labitt

    (Laboratory of Virology and Infectious Diseases, The Rockefeller University)

  • Christian Gaebler

    (Laboratory of Molecular Immunology, The Rockefeller University
    Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden)

  • Paola M. Marcovecchio

    (California Institute of Technology)

  • Reha-Baris Incesu

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Thomas R. Eisenreich

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Paul D. Bieniasz

    (Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

  • Michael S. Seaman

    (Beth Israel Deaconess Medical Center)

  • Pamela J. Bjorkman

    (California Institute of Technology
    Howard Hughes Medical Institute, California Institute of Technology)

  • Jeffrey V. Ravetch

    (Laboratory of Molecular Genetics and Immunology, The Rockefeller University)

  • Alexander Ploss

    (Laboratory of Virology and Infectious Diseases, The Rockefeller University)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

Abstract

Passive immunotherapy with a combination of neutralizing monoclonal antibodies is shown to be effective in suppressing HIV replication in a humanized mouse model.

Suggested Citation

  • Florian Klein & Ariel Halper-Stromberg & Joshua A. Horwitz & Henning Gruell & Johannes F. Scheid & Stylianos Bournazos & Hugo Mouquet & Linda A. Spatz & Ron Diskin & Alexander Abadir & Trinity Zang & , 2012. "HIV therapy by a combination of broadly neutralizing antibodies in humanized mice," Nature, Nature, vol. 492(7427), pages 118-122, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7427:d:10.1038_nature11604
    DOI: 10.1038/nature11604
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    Citations

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    Cited by:

    1. Craig A Magaret & David C Benkeser & Brian D Williamson & Bhavesh R Borate & Lindsay N Carpp & Ivelin S Georgiev & Ian Setliff & Adam S Dingens & Noah Simon & Marco Carone & Christopher Simpkins & Dav, 2019. "Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features," PLOS Computational Biology, Public Library of Science, vol. 15(4), pages 1-35, April.
    2. Christoph Kreer & Cosimo Lupo & Meryem S. Ercanoglu & Lutz Gieselmann & Natanael Spisak & Jan Grossbach & Maike Schlotz & Philipp Schommers & Henning Gruell & Leona Dold & Andreas Beyer & Armita Nourm, 2023. "Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Lucia Reh & Carsten Magnus & Merle Schanz & Jacqueline Weber & Therese Uhr & Peter Rusert & Alexandra Trkola, 2015. "Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent," PLOS Pathogens, Public Library of Science, vol. 11(7), pages 1-34, July.
    4. Nicole A Doria-Rose & Han R Altae-Tran & Ryan S Roark & Stephen D Schmidt & Matthew S Sutton & Mark K Louder & Gwo-Yu Chuang & Robert T Bailer & Valerie Cortez & Rui Kong & Krisha McKee & Sijy O’Dell , 2017. "Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting," PLOS Pathogens, Public Library of Science, vol. 13(1), pages 1-29, January.
    5. Anna Hake & Nico Pfeifer, 2017. "Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-23, October.

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