IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v488y2012i7413d10.1038_nature11282.html
   My bibliography  Save this article

Recurrent R-spondin fusions in colon cancer

Author

Listed:
  • Somasekar Seshagiri

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Eric W. Stawiski

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Steffen Durinck

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Zora Modrusan

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Elaine E. Storm

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Caitlin B. Conboy

    (Cell Biology and Development, Masonic Cancer Center, University of Minnesota)

  • Subhra Chaudhuri

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Yinghui Guan

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Vasantharajan Janakiraman

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Bijay S. Jaiswal

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Joseph Guillory

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Connie Ha

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Gerrit J. P. Dijkgraaf

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jeremy Stinson

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Florian Gnad

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Melanie A. Huntley

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jeremiah D. Degenhardt

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Peter M. Haverty

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Richard Bourgon

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Weiru Wang

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Hartmut Koeppen

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Robert Gentleman

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Timothy K. Starr

    (Gynecology & Women’s Health, Masonic Cancer Center, University of Minnesota)

  • Zemin Zhang

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • David A. Largaespada

    (Cell Biology and Development, Masonic Cancer Center, University of Minnesota)

  • Thomas D. Wu

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Frederic J. de Sauvage

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.

Suggested Citation

  • Somasekar Seshagiri & Eric W. Stawiski & Steffen Durinck & Zora Modrusan & Elaine E. Storm & Caitlin B. Conboy & Subhra Chaudhuri & Yinghui Guan & Vasantharajan Janakiraman & Bijay S. Jaiswal & Joseph, 2012. "Recurrent R-spondin fusions in colon cancer," Nature, Nature, vol. 488(7413), pages 660-664, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11282
    DOI: 10.1038/nature11282
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11282
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11282?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Victoria H. Ng & Zachary Spencer & Leif R. Neitzel & Anmada Nayak & Matthew A. Loberg & Chen Shen & Sara N. Kassel & Heather K. Kroh & Zhenyi An & Christin C. Anthony & Jamal M. Bryant & Amanda Lawson, 2023. "The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Lo, Andrew W. & Thakor, Richard T., 2023. "Financial intermediation and the funding of biomedical innovation: A review," Journal of Financial Intermediation, Elsevier, vol. 54(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11282. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.