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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Author

Listed:
  • Hyejung Won

    (Department of Biological Sciences
    National Creative Research Initiative Center for Synaptogenesis)

  • Hye-Ryeon Lee

    (National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul 151-747, Korea)

  • Heon Yung Gee

    (Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine)

  • Won Mah

    (Department of Biological Sciences
    National Creative Research Initiative Center for Synaptogenesis)

  • Jae-Ick Kim

    (National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul 151-747, Korea)

  • Jiseok Lee

    (Department of Biological Sciences
    National Creative Research Initiative Center for Synaptogenesis)

  • Seungmin Ha

    (Department of Biological Sciences
    National Creative Research Initiative Center for Synaptogenesis)

  • Changuk Chung

    (Department of Biological Sciences
    National Creative Research Initiative Center for Synaptogenesis)

  • Eun Suk Jung

    (Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine)

  • Yi Sul Cho

    (School of Dentistry, Kyungpook National University)

  • Sae-Geun Park

    (Department of Biological Sciences)

  • Jung-Soo Lee

    (Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine)

  • Kyungmin Lee

    (School of Medicine, Brain Science & Engineering Institute, Kyungpook National University)

  • Daesoo Kim

    (Department of Biological Sciences)

  • Yong Chul Bae

    (School of Dentistry, Kyungpook National University)

  • Bong-Kiun Kaang

    (National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul 151-747, Korea
    Seoul National University)

  • Min Goo Lee

    (Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine)

  • Eunjoon Kim

    (Department of Biological Sciences
    National Creative Research Initiative Center for Synaptogenesis
    Graduate School of Nanoscience and Technology (World Class University), KAIST, Daejeon 305-701, Korea
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

Abstract

Mutations in SHANK2 have been associated with autism spectrum disorders in humans; here, Shank2 mutant mice are shown to exhibit autistic-like behaviours that can be improved by restoring decreased NMDA receptor function.

Suggested Citation

  • Hyejung Won & Hye-Ryeon Lee & Heon Yung Gee & Won Mah & Jae-Ick Kim & Jiseok Lee & Seungmin Ha & Changuk Chung & Eun Suk Jung & Yi Sul Cho & Sae-Geun Park & Jung-Soo Lee & Kyungmin Lee & Daesoo Kim & , 2012. "Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function," Nature, Nature, vol. 486(7402), pages 261-265, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7402:d:10.1038_nature11208
    DOI: 10.1038/nature11208
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    Citations

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    Cited by:

    1. Tetsushi Sadakata & Yo Shinoda & Akira Sato & Hirotoshi Iguchi & Chiaki Ishii & Makoto Matsuo & Ryosuke Yamaga & Teiichi Furuichi, 2013. "Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2/Cadps2 Copy Number and Alternative Splicing Variants," IJERPH, MDPI, vol. 10(12), pages 1-19, November.
    2. Zhen Zheng & Tingting Zhu & Yi Qu & Dezhi Mu, 2016. "Blood Glutamate Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-12, July.
    3. Paris Mazzachi & Ella McDonald & Zarina Greenberg & Alejandra Noreña Puerta & Jenne Tran & Manam Inushi De Silva & Cade Christensen & Robert Adams & Sebastian Loskarn & Helen Beard & Michael Zabolocki, 2026. "Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks," Nature Communications, Nature, vol. 17(1), pages 1-23, December.
    4. Pascal Grumbach & Jan Kasper & Joerg F. Hipp & Anna Forsyth & Sofie L. Valk & Suresh Muthukumaraswamy & Simon B. Eickhoff & Leonhard Schilbach & Juergen Dukart, 2025. "Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    5. Fernando S. Goes & Leonardo Collado-Torres & Peter P. Zandi & Louise Huuki-Myers & Ran Tao & Andrew E. Jaffe & Geo Pertea & Joo Heon Shin & Daniel R. Weinberger & Joel E. Kleinman & Thomas M. Hyde, 2025. "Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons," Nature Communications, Nature, vol. 16(1), pages 1-15, December.

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