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Antibiotic resistance is ancient

Author

Listed:
  • Vanessa M. D’Costa

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

  • Christine E. King

    (McMaster Ancient DNA Centre, McMaster University
    McMaster University)

  • Lindsay Kalan

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

  • Mariya Morar

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

  • Wilson W. L. Sung

    (McMaster University)

  • Carsten Schwarz

    (McMaster Ancient DNA Centre, McMaster University)

  • Duane Froese

    (University of Alberta)

  • Grant Zazula

    (Yukon Palaeontology Program, Yukon Government, PO Box 2703)

  • Fabrice Calmels

    (University of Alberta)

  • Regis Debruyne

    (Muséum National d’Histoire Naturelle, UMR 7206 Eco-anthropologie, 57 rue Cuvier, CP139)

  • G. Brian Golding

    (McMaster University)

  • Hendrik N. Poinar

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster Ancient DNA Centre, McMaster University
    McMaster University)

  • Gerard D. Wright

    (Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
    McMaster University)

Abstract

The roots of antibiotic resistance Antibiotic resistance is thought to have evolved long before naturally occurring antibiotics and their derivatives were used to treat human disease, but direct evidence for genes that encode resistance has been lacking. Now, an ancient vancomycin-resistance gene has been recovered from 30,000-year-old samples of Siberian permafrost, and the three-dimensional structure of its product has been compared with that of its modern counterpart. There are minor structural differences between the ancient and modern versions, but the differences are not reflected in enzyme function.

Suggested Citation

  • Vanessa M. D’Costa & Christine E. King & Lindsay Kalan & Mariya Morar & Wilson W. L. Sung & Carsten Schwarz & Duane Froese & Grant Zazula & Fabrice Calmels & Regis Debruyne & G. Brian Golding & Hendri, 2011. "Antibiotic resistance is ancient," Nature, Nature, vol. 477(7365), pages 457-461, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10388
    DOI: 10.1038/nature10388
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    Cited by:

    1. Na Li & Hongna Li & Changxiong Zhu & Chong Liu & Guofeng Su & Jianguo Chen, 2022. "Controlling AMR in the Pig Industry: Is It Enough to Restrict Heavy Metals?," IJERPH, MDPI, vol. 19(18), pages 1-12, September.
    2. Sharon P. Nappier & Krista Liguori & Audrey M. Ichida & Jill R. Stewart & Kaedra R. Jones, 2020. "Antibiotic Resistance in Recreational Waters: State of the Science," IJERPH, MDPI, vol. 17(21), pages 1-28, October.
    3. Rita Batista & Margarida Saraiva & Teresa Lopes & Leonor Silveira & Anabela Coelho & Rosália Furtado & Rita Castro & Cristina Belo Correia & David Rodrigues & Pedro Henriques & Sara Lóio & Vanessa Soe, 2022. "Genotypic and Phenotypic Characterization of Pathogenic Escherichia coli , Salmonella spp., and Campylobacter spp., in Free-Living Birds in Mainland Portugal," IJERPH, MDPI, vol. 20(1), pages 1-14, December.
    4. Nolonwabo Nontongana & Timothy Sibanda & Elvis Ngwenya & Anthony I. Okoh, 2014. "Prevalence and Antibiogram Profiling of Escherichia coli Pathotypes Isolated from the Kat River and the Fort Beaufort Abstraction Water," IJERPH, MDPI, vol. 11(8), pages 1-15, August.
    5. Asit Kumar Chakraborty, 2017. "Mechanisms of AMR: Mdr Genes and Antibiotics Decoys Retard the New Antibiotic Discovery against Superbugs," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(1), pages 1-5, June.
    6. Shahnawaz Hassan & Zulaykha Khurshid & Sabreena & Bikram Singh Bali & Bashir Ah Ganai & R. Z. Sayyed & Peter Poczai & Muzafar Zaman, 2022. "A Critical Assessment of the Congruency between Environmental DNA and Palaeoecology for the Biodiversity Monitoring and Palaeoenvironmental Reconstruction," IJERPH, MDPI, vol. 19(15), pages 1-25, August.
    7. Łukasz Jałowiecki & Jakub Hubeny & Monika Harnisz & Grażyna Płaza, 2021. "Seasonal and Technological Shifts of the WHO Priority Multi-Resistant Pathogens in Municipal Wastewater Treatment Plant and Its Receiving Surface Water: A Case Study," IJERPH, MDPI, vol. 19(1), pages 1-13, December.
    8. Iyiola Olatunji Oladunjoye & Yusuf Amuda Tajudeen & Habeebullah Jayeola Oladipo & Mona Said El-Sherbini, 2022. "Planetary Health and Traditional Medicine: A Potential Synergistic Approach to Tackle Antimicrobial Resistance," Challenges, MDPI, vol. 13(1), pages 1-10, June.
    9. Ming Ni & Antoine L Decrulle & Fanette Fontaine & Alice Demarez & Francois Taddei & Ariel B Lindner, 2012. "Pre-Disposition and Epigenetics Govern Variation in Bacterial Survival upon Stress," PLOS Genetics, Public Library of Science, vol. 8(12), pages 1-11, December.
    10. Stacy Slobodiuk & Caitlin Niven & Greer Arthur & Siddhartha Thakur & Ayse Ercumen, 2021. "Does Irrigation with Treated and Untreated Wastewater Increase Antimicrobial Resistance in Soil and Water: A Systematic Review," IJERPH, MDPI, vol. 18(21), pages 1-19, October.
    11. Valentin Duvauchelle & Elsa Causse & Julien Michon & Patrick Rateau & Karine Weiss & Patrick Meffre & Zohra Benfodda, 2021. "Evaluation of Knowledge and Risk Perception about Antibiotic Resistance in Biology and Mathematics Young Students in Nîmes University in France," IJERPH, MDPI, vol. 18(18), pages 1-12, September.
    12. Laura C. Scott & Nicholas Lee & Tiong Gim Aw, 2020. "Antibiotic Resistance in Minimally Human-Impacted Environments," IJERPH, MDPI, vol. 17(11), pages 1-12, June.
    13. Merja Ahonen & Anne Kahru & Angela Ivask & Kaja Kasemets & Siiri Kõljalg & Paride Mantecca & Ivana Vinković Vrček & Minna M. Keinänen-Toivola & Francy Crijns, 2017. "Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI," IJERPH, MDPI, vol. 14(4), pages 1-23, March.
    14. Milva Pepi & Silvano Focardi, 2021. "Antibiotic-Resistant Bacteria in Aquaculture and Climate Change: A Challenge for Health in the Mediterranean Area," IJERPH, MDPI, vol. 18(11), pages 1-31, May.
    15. Na Li & Chong Liu & Zhiguo Zhang & Hongna Li & Tingting Song & Ting Liang & Binxu Li & Luyao Li & Shuo Feng & Qianqian Su & Jing Ye & Changxiong Zhu, 2019. "Research and Technological Advances Regarding the Study of the Spread of Antimicrobial Resistance Genes and Antimicrobial-Resistant Bacteria Related to Animal Husbandry," IJERPH, MDPI, vol. 16(24), pages 1-19, December.

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