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Hundreds of variants clustered in genomic loci and biological pathways affect human height

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Listed:
  • Hana Lango Allen

    (Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter)

  • Karol Estrada

    (Erasmus Medical Centre
    Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Guillaume Lettre

    (Montreal Heart Institute
    Université de Montréal)

  • Sonja I. Berndt

    (National Cancer Institute, National Institutes of Health)

  • Michael N. Weedon

    (Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter)

  • Fernando Rivadeneira

    (Erasmus Medical Centre
    Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Cristen J. Willer

    (Center for Statistical Genetics, University of Michigan)

  • Anne U. Jackson

    (Center for Statistical Genetics, University of Michigan)

  • Sailaja Vedantam

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute)

  • Soumya Raychaudhuri

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School)

  • Teresa Ferreira

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Andrew R. Wood

    (Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter)

  • Robert J. Weyant

    (Center for Statistical Genetics, University of Michigan)

  • Ayellet V. Segrè

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Center for Human Genetic Research, Massachusetts General Hospital
    Massachusetts General Hospital)

  • Elizabeth K. Speliotes

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute
    Massachusetts General Hospital)

  • Eleanor Wheeler

    (Wellcome Trust Sanger Institute, Hinxton)

  • Nicole Soranzo

    (Wellcome Trust Sanger Institute, Hinxton
    King’s College London)

  • Ju-Hyun Park

    (National Cancer Institute, National Institutes of Health)

  • Jian Yang

    (Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research)

  • Daniel Gudbjartsson

    (deCODE Genetics)

  • Nancy L. Heard-Costa

    (Boston University School of Medicine)

  • Joshua C. Randall

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Lu Qi

    (Harvard School of Public Health
    Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School)

  • Albert Vernon Smith

    (Icelandic Heart Association
    University of Iceland)

  • Reedik Mägi

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Tomi Pastinen

    (McGill University and Genome Québec Innovation Centre
    McGill University Health Centre, McGill University
    McGill University Health Centre, McGill University)

  • Liming Liang

    (Harvard School of Public Health)

  • Iris M. Heid

    (Regensburg University Medical Center
    Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Jian’an Luan

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Gudmar Thorleifsson

    (deCODE Genetics)

  • Thomas W. Winkler

    (Regensburg University Medical Center)

  • Michael E. Goddard

    (Faculty of Land and Environment, University of Melbourne
    Department of Primary Industries)

  • Ken Sin Lo

    (Montreal Heart Institute)

  • Cameron Palmer

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute)

  • Tsegaselassie Workalemahu

    (Harvard School of Public Health)

  • Yurii S. Aulchenko

    (Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Åsa Johansson

    (Rudbeck Laboratory, University of Uppsala
    Faculty of Medicine, Norwegian University of Science and Technology (NTNU))

  • M. Carola Zillikens

    (Erasmus Medical Centre)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • Tõnu Esko

    (Estonian Genome Center, University of Tartu
    Estonian Biocenter
    Institute of Molecular and Cell Biology, University of Tartu)

  • Toby Johnson

    (University of Lausanne
    Swiss Institute of Bioinformatics
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.
    Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.)

  • Shamika Ketkar

    (Washington University School of Medicine)

  • Peter Kraft

    (Harvard School of Public Health
    Harvard School of Public Health)

  • Massimo Mangino

    (King’s College London)

  • Inga Prokopenko

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford)

  • Devin Absher

    (Hudson Alpha Institute for Biotechnology)

  • Eva Albrecht

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Florian Ernst

    (Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald)

  • Nicole L. Glazer

    (University of Washington)

  • Caroline Hayward

    (MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital)

  • Jouke-Jan Hottenga

    (VU University Amsterdam)

  • Kevin B. Jacobs

    (Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick)

  • Joshua W. Knowles

    (Stanford University School of Medicine)

  • Zoltán Kutalik

    (University of Lausanne
    Swiss Institute of Bioinformatics)

  • Keri L. Monda

    (School of Public Health, University of North Carolina at Chapel Hill)

  • Ozren Polasek

    (Andrija Stampar School of Public Health, Medical School, University of Zagreb
    Gen-Info Ltd)

  • Michael Preuss

    (Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik)

  • Nigel W. Rayner

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford)

  • Neil R. Robertson

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford)

  • Valgerdur Steinthorsdottir

    (deCODE Genetics)

  • Jonathan P. Tyrer

    (University of Cambridge)

  • Benjamin F. Voight

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Center for Human Genetic Research, Massachusetts General Hospital
    Massachusetts General Hospital)

  • Fredrik Wiklund

    (Karolinska Institutet)

  • Jianfeng Xu

    (Center for Human Genomics, Wake Forest University)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Dale R. Nyholt

    (Neurogenetics Laboratory, Queensland Institute of Medical Research)

  • Niina Pellikka

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    National Institute for Health and Welfare, Unit of Public Health Genomics)

  • Markus Perola

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    National Institute for Health and Welfare, Unit of Public Health Genomics)

  • John R. B. Perry

    (Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter)

  • Ida Surakka

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    National Institute for Health and Welfare, Unit of Public Health Genomics)

  • Mari-Liis Tammesoo

    (Estonian Genome Center, University of Tartu)

  • Elizabeth L. Altmaier

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute)

  • Najaf Amin

    (Erasmus Medical Centre)

  • Thor Aspelund

    (Icelandic Heart Association
    University of Iceland)

  • Tushar Bhangale

    (University of Washington)

  • Gabrielle Boucher

    (Montreal Heart Institute)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Constance Chen

    (Program in Molecular and Genetic Epidemiology, Harvard School of Public Health)

  • Lachlan Coin

    (School of Public Health, Faculty of Medicine, Imperial College London)

  • Matthew N. Cooper

    (Centre for Genetic Epidemiology and Biostatistics, University of Western Australia)

  • Anna L. Dixon

    (Royal National Hospital for Rheumatic Diseases and University of Bath)

  • Quince Gibson

    (University of Maryland School of Medicine)

  • Elin Grundberg

    (Wellcome Trust Sanger Institute, Hinxton
    McGill University and Genome Québec Innovation Centre
    McGill University Health Centre, McGill University)

  • Ke Hao

    (Rosetta Inpharmatics, a Wholly Owned Subsidiary of Merck & Co Inc.)

  • M. Juhani Junttila

    (University of Oulu)

  • Lee M. Kaplan

    (Massachusetts General Hospital
    Harvard Medical School
    MGH Weight Center, Massachusetts General Hospital)

  • Johannes Kettunen

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    National Institute for Health and Welfare, Unit of Public Health Genomics)

  • Inke R. König

    (Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik)

  • Tony Kwan

    (McGill University and Genome Québec Innovation Centre
    McGill University Health Centre, McGill University)

  • Robert W. Lawrence

    (Centre for Genetic Epidemiology and Biostatistics, University of Western Australia)

  • Douglas F. Levinson

    (Stanford University School of Medicine)

  • Mattias Lorentzon

    (Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Barbara McKnight

    (University of Washington)

  • Andrew P. Morris

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Martina Müller

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
    Ludwig-Maximilians- Universität, University Hospital Grosshadern
    Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology)

  • Julius Suh Ngwa

    (Boston University School of Public Health)

  • Shaun Purcell

    (Center for Human Genetic Research, Massachusetts General Hospital
    The Broad Institute of Harvard and MIT
    Harvard Medical School)

  • Suzanne Rafelt

    (University of Leicester, Glenfield Hospital)

  • Rany M. Salem

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute)

  • Erika Salvi

    (University of Milan, Surgery and Dentistry
    KOS Genetic Srl)

  • Serena Sanna

    (Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042 Cagliari, Italy.)

  • Jianxin Shi

    (National Cancer Institute, National Institutes of Health)

  • Ulla Sovio

    (School of Public Health, Faculty of Medicine, Imperial College London)

  • John R. Thompson

    (Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital
    University of Leicester)

  • Michael C. Turchin

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute)

  • Liesbeth Vandenput

    (Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Dominique J. Verlaan

    (McGill University and Genome Québec Innovation Centre
    McGill University Health Centre, McGill University)

  • Veronique Vitart

    (MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital)

  • Charles C. White

    (Boston University School of Public Health)

  • Andreas Ziegler

    (Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik)

  • Peter Almgren

    (Lund University Diabetes Centre, Lund University)

  • Anthony J. Balmforth

    (Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds)

  • Harry Campbell

    (Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK.)

  • Lorena Citterio

    (University Vita-Salute San Raffaele)

  • Alessandro De Grandi

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck)

  • Anna Dominiczak

    (British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow)

  • Jubao Duan

    (Northshore University Healthsystem)

  • Paul Elliott

    (School of Public Health, Faculty of Medicine, Imperial College London)

  • Roberto Elosua

    (Cardiovascular Epidemiology and Genetics, Institut Municipal D’investigacio Medica and CIBER Epidemiología y Salud Pública)

  • Johan G. Eriksson

    (University of Helsinki
    National Institute for Health and Welfare
    Helsinki University Central Hospital, Unit of General Practice
    Folkhalsan Research Centre)

  • Nelson B. Freimer

    (Center for Neurobehavioral Genetics, University of California)

  • Eco J. C. Geus

    (VU University Amsterdam)

  • Nicola Glorioso

    (Hypertension and Cardiovascular Prevention Center, University of Sassari)

  • Shen Haiqing

    (University of Maryland School of Medicine)

  • Anna-Liisa Hartikainen

    (University of Oulu)

  • Aki S. Havulinna

    (National Institute for Health and Welfare, Chronic Disease Epidemiology and Prevention Unit)

  • Andrew A. Hicks

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck)

  • Jennie Hui

    (Centre for Genetic Epidemiology and Biostatistics, University of Western Australia
    PathWest Laboratory of Western Australia, J Block, QEII Medical Centre
    Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital)

  • Wilmar Igl

    (Rudbeck Laboratory, University of Uppsala)

  • Thomas Illig

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Antti Jula

    (National Institute for Health and Welfare, Population Studies Unit)

  • Eero Kajantie

    (National Institute for Health and Welfare)

  • Tuomas O. Kilpeläinen

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Markku Koiranen

    (Institute of Health Sciences, University of Oulu)

  • Ivana Kolcic

    (Andrija Stampar School of Public Health, Medical School, University of Zagreb)

  • Seppo Koskinen

    (National Institute for Health and Welfare, Chronic Disease Epidemiology and Prevention Unit)

  • Peter Kovacs

    (Interdisciplinary Centre for Clinical Research, University of Leipzig)

  • Jaana Laitinen

    (Finnish Institute of Occupational Health)

  • Jianjun Liu

    (Human Genetics, Genome Institute of Singapore)

  • Marja-Liisa Lokki

    (Transplantation Laboratory, Haartman Institute, University of Helsinki)

  • Ana Marusic

    (Croatian Centre for Global Health, School of Medicine, University of Split)

  • Andrea Maschio

    (Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042 Cagliari, Italy.)

  • Thomas Meitinger

    (Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München
    Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Antonella Mulas

    (Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042 Cagliari, Italy.)

  • Guillaume Paré

    (McMaster University)

  • Alex N. Parker

    (Amgen)

  • John F. Peden

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.)

  • Astrid Petersmann

    (Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Greifswald)

  • Irene Pichler

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck)

  • Kirsi H. Pietiläinen

    (Finnish Twin Cohort Study, University of Helsinki
    Obesity Research unit, Helsinki University Central Hospital)

  • Anneli Pouta

    (University of Oulu
    National Institute for Health and Welfare)

  • Martin Ridderstråle

    (Lund University)

  • Jerome I. Rotter

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Jennifer G. Sambrook

    (University of Cambridge
    NHS Blood and Transplant, Cambridge Centre)

  • Alan R. Sanders

    (Northshore University Healthsystem)

  • Carsten Oliver Schmidt

    (Institut für Community Medicine)

  • Juha Sinisalo

    (Cardiovascular Laboratory, Helsinki University Central Hospital)

  • Jan H. Smit

    (VU University Medical Center)

  • Heather M. Stringham

    (Center for Statistical Genetics, University of Michigan)

  • G. Bragi Walters

    (deCODE Genetics)

  • Elisabeth Widen

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki)

  • Sarah H. Wild

    (Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK.)

  • Gonneke Willemsen

    (VU University Amsterdam)

  • Laura Zagato

    (University Vita-Salute San Raffaele)

  • Lina Zgaga

    (Andrija Stampar School of Public Health, Medical School, University of Zagreb)

  • Paavo Zitting

    (Lapland Central Hospital)

  • Helene Alavere

    (Estonian Genome Center, University of Tartu)

  • Martin Farrall

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
    Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics)

  • Wendy L. McArdle

    (Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, University of Bristol)

  • Mari Nelis

    (Estonian Genome Center, University of Tartu
    Estonian Biocenter
    Institute of Molecular and Cell Biology, University of Tartu)

  • Marjolein J. Peters

    (Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Samuli Ripatti

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    National Institute for Health and Welfare, Unit of Public Health Genomics)

  • Joyce B. J. van Meurs

    (Erasmus Medical Centre
    Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Katja K. Aben

    (Comprehensive Cancer Center East)

  • Kristin G. Ardlie

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology)

  • Jacques S. Beckmann

    (University of Lausanne
    Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital)

  • John P. Beilby

    (PathWest Laboratory of Western Australia, J Block, QEII Medical Centre
    Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital
    School of Pathology and Laboratory Medicine, University of Western Australia)

  • Richard N. Bergman

    (Keck School of Medicine, University of Southern California)

  • Sven Bergmann

    (University of Lausanne
    Swiss Institute of Bioinformatics)

  • Francis S. Collins

    (National Human Genome Research Institute, National Institutes of Health)

  • Daniele Cusi

    (University of Milan, Surgery and Dentistry)

  • Martin den Heijer

    (Radboud University Nijmegen Medical Centre)

  • Gudny Eiriksdottir

    (Icelandic Heart Association)

  • Pablo V. Gejman

    (Northshore University Healthsystem)

  • Alistair S. Hall

    (Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds)

  • Anders Hamsten

    (Atherosclerosis Research Unit, Solna, Karolinska Institutet, Karolinska University Hospital)

  • Heikki V. Huikuri

    (University of Oulu)

  • Carlos Iribarren

    (Kaiser Permanente Northern California
    University of California, San Francisco)

  • Mika Kähönen

    (University of Tampere and Tampere University Hospital)

  • Jaakko Kaprio

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    Finnish Twin Cohort Study, University of Helsinki
    National Institute for Health and Welfare, Unit for Child and Adolescent Mental Health)

  • Sekar Kathiresan

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Center for Human Genetic Research, Massachusetts General Hospital
    Massachusetts General Hospital
    Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University)

  • Lambertus Kiemeney

    (Comprehensive Cancer Center East
    Biostatistics and HTA, Radboud University Nijmegen Medical Centre
    Radboud University Nijmegen Medical Centre)

  • Thomas Kocher

    (Zentrum für Zahn-, Mund- und Kieferheilkunde)

  • Lenore J. Launer

    (Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health)

  • Terho Lehtimäki

    (University of Tampere and Tampere University Hospital)

  • Olle Melander

    (Lund University)

  • Tom H. Mosley Jr

    (University of Mississippi Medical Center)

  • Arthur W. Musk

    (Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital
    School of Medicine and Pharmacology, University of Western Australia)

  • Markku S. Nieminen

    (Cardiovascular Laboratory, Helsinki University Central Hospital)

  • Christopher J. O’Donnell

    (Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University
    National, Lung, and Blood Institute, National Institutes of Health)

  • Claes Ohlsson

    (Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Ben Oostra

    (Erasmus Medical Centre)

  • Lyle J. Palmer

    (Centre for Genetic Epidemiology and Biostatistics, University of Western Australia
    Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital)

  • Olli Raitakari

    (Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital)

  • Paul M. Ridker

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • John D. Rioux

    (Montreal Heart Institute
    Université de Montréal)

  • Aila Rissanen

    (Obesity Research unit, Helsinki University Central Hospital)

  • Carlo Rivolta

    (University of Lausanne)

  • Heribert Schunkert

    (Universität zu Lübeck, Medizinische Klinik II)

  • Alan R. Shuldiner

    (University of Maryland School of Medicine
    Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center)

  • David S. Siscovick

    (Cardiovascular Health Research Unit, University of Washington
    University of Washington)

  • Michael Stumvoll

    (University of Leipzig
    LIFE Study Centre, University of Leipzig)

  • Anke Tönjes

    (University of Leipzig
    Coordination Centre for Clinical Trials, University of Leipzig, Härtelstrasse 16–18, 04103 Leipzig, Germany.)

  • Jaakko Tuomilehto

    (National Institute for Health and Welfare, Diabetes Prevention Unit
    Hjelt Institute, University of Helsinki
    South Ostrobothnia Central Hospital)

  • Gert-Jan van Ommen

    (Leiden University Medical Center)

  • Jorma Viikari

    (University of Turku and Turku University Hospital)

  • Andrew C. Heath

    (Washington University School of Medicine)

  • Nicholas G. Martin

    (Genetic Epidemiology Laboratory, Queensland Institute of Medical Research)

  • Grant W. Montgomery

    (Molecular Epidemiology Laboratory, Queensland Institute of Medical Research)

  • Michael A. Province

    (Washington University School of Medicine
    Division of Biostatistics,Washington University School of Medicine)

  • Manfred Kayser

    (Erasmus Medical Centre)

  • Alice M. Arnold

    (University of Washington
    Collaborative Health Studies Coordinating Center)

  • Larry D. Atwood

    (Boston University School of Medicine)

  • Eric Boerwinkle

    (University of Texas Health Science Center)

  • Stephen J. Chanock

    (National Cancer Institute, National Institutes of Health)

  • Panos Deloukas

    (Wellcome Trust Sanger Institute, Hinxton)

  • Christian Gieger

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Henrik Grönberg

    (Karolinska Institutet)

  • Per Hall

    (Karolinska Institutet)

  • Andrew T. Hattersley

    (Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter)

  • Christian Hengstenberg

    (Klinik und Poliklinik für Innere Medizin II, Universität Regensburg
    Regensburg University Medical Center, Innere Medizin II)

  • Wolfgang Hoffman

    (Institut für Community Medicine)

  • G. Mark Lathrop

    (Centre National de Genotypage, Evry, Paris 91057, France.)

  • Veikko Salomaa

    (National Institute for Health and Welfare, Chronic Disease Epidemiology and Prevention Unit)

  • Stefan Schreiber

    (Christian-Albrechts-University, University Hospital Schleswig-Holstein, Schittenhelmstrasse 12)

  • Manuela Uda

    (Istituto di Neurogenetica e Neurofarmacologia del CNR, Monserrato, 09042 Cagliari, Italy.)

  • Dawn Waterworth

    (GlaxoSmithKline)

  • Alan F. Wright

    (MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital)

  • Themistocles L. Assimes

    (Stanford University School of Medicine)

  • Inês Barroso

    (Wellcome Trust Sanger Institute, Hinxton
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Albert Hofman

    (Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Karen L. Mohlke

    (University of North Carolina)

  • Dorret I. Boomsma

    (VU University Amsterdam)

  • Mark J. Caulfield

    (Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.)

  • L. Adrienne Cupples

    (Boston University School of Public Health)

  • Jeanette Erdmann

    (Universität zu Lübeck, Medizinische Klinik II)

  • Caroline S. Fox

    (National Heart, Lung, and Blood Institute, Framingham Heart Study)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    University of Iceland)

  • Ulf Gyllensten

    (Rudbeck Laboratory, University of Uppsala)

  • Tamara B. Harris

    (Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health)

  • Richard B. Hayes

    (New York University Medical Center)

  • Marjo-Riitta Jarvelin

    (School of Public Health, Faculty of Medicine, Imperial College London
    Institute of Health Sciences, University of Oulu
    National Institute for Health and Welfare
    Biocenter Oulu, University of Oulu)

  • Vincent Mooser

    (GlaxoSmithKline)

  • Patricia B. Munroe

    (Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.)

  • Willem H. Ouwehand

    (Wellcome Trust Sanger Institute, Hinxton
    University of Cambridge
    NHS Blood and Transplant, Cambridge Centre)

  • Brenda W. Penninx

    (VU University Medical Center
    Leiden University Medical Centre
    University Medical Centre Groningen)

  • Peter P. Pramstaller

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, 39100, Italy. Affiliated Institute of the University of Lübeck
    General Central Hospital
    University of Lübeck)

  • Thomas Quertermous

    (Stanford University School of Medicine)

  • Igor Rudan

    (MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital
    Croatian Centre for Global Health, School of Medicine, University of Split)

  • Nilesh J. Samani

    (University of Leicester, Glenfield Hospital
    Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital)

  • Timothy D. Spector

    (King’s College London)

  • Henry Völzke

    (Institut für Community Medicine)

  • Hugh Watkins

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Oxford, Level 6 West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.)

  • James F. Wilson

    (Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK.)

  • Leif C. Groop

    (Lund University Diabetes Centre, Lund University)

  • Talin Haritunians

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Frank B. Hu

    (Harvard School of Public Health
    Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Robert C. Kaplan

    (Albert Einstein College of Medicine)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu
    Estonian Biocenter
    Institute of Molecular and Cell Biology, University of Tartu)

  • Kari E. North

    (School of Public Health, University of North Carolina at Chapel Hill
    Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill)

  • David Schlessinger

    (Laboratory of Genetics, National Institute on Aging)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • David J. Hunter

    (Harvard School of Public Health
    Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Jeffrey R. O’Connell

    (University of Maryland School of Medicine)

  • David P. Strachan

    (St George’s, University of London)

  • H.-Erich Wichmann

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
    Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology
    Klinikum Grosshadern)

  • Ingrid B. Borecki

    (Washington University School of Medicine
    Division of Biostatistics,Washington University School of Medicine)

  • Cornelia M. van Duijn

    (Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Eric E. Schadt

    (Pacific Biosciences
    Sage Bionetworks)

  • Unnur Thorsteinsdottir

    (deCODE Genetics
    Faculty of Medicine, University of Iceland)

  • Leena Peltonen

    (Wellcome Trust Sanger Institute, Hinxton
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    National Institute for Health and Welfare, Unit of Public Health Genomics
    The Broad Institute of Harvard and MIT)

  • André G. Uitterlinden

    (Erasmus Medical Centre
    Erasmus Medical Centre
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Peter M. Visscher

    (Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research)

  • Nilanjan Chatterjee

    (National Cancer Institute, National Institutes of Health)

  • Ruth J. F. Loos

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Michael Boehnke

    (Center for Statistical Genetics, University of Michigan)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
    NIHR Oxford Biomedical Research Centre, Churchill Hospital)

  • Erik Ingelsson

    (Karolinska Institutet)

  • Cecilia M. Lindgren

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford)

  • Gonçalo R. Abecasis

    (Center for Statistical Genetics, University of Michigan)

  • Kari Stefansson

    (deCODE Genetics
    Faculty of Medicine, University of Iceland)

  • Timothy M. Frayling

    (Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter)

  • Joel N. Hirschhorn

    (Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute
    Harvard Medical School)

Abstract

The genetics of human height A genome-wide association (GWA) study of more than 180,000 individuals has identified hundreds of genetic variants in at least 180 loci associated with adult human height. The loci are not clustered randomly but are enriched for genes involved in growth-related processes that influence adult height. This demonstrates that GWA studies of common human traits, and therefore of many diseases, can identify large numbers of loci that implicate potential causal genes.

Suggested Citation

  • Hana Lango Allen & Karol Estrada & Guillaume Lettre & Sonja I. Berndt & Michael N. Weedon & Fernando Rivadeneira & Cristen J. Willer & Anne U. Jackson & Sailaja Vedantam & Soumya Raychaudhuri & Teresa, 2010. "Hundreds of variants clustered in genomic loci and biological pathways affect human height," Nature, Nature, vol. 467(7317), pages 832-838, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7317:d:10.1038_nature09410
    DOI: 10.1038/nature09410
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    Cited by:

    1. Rita Dias Pereira & Pietro Biroli & Titus Galama & Stephanie von Hinke & Hans van Kippersluis & Cornelius A. Rietveld & Kevin Thom, 2022. "Gene-Environment Interplay in the Social Sciences," Papers 2203.02198, arXiv.org, revised Aug 2022.
    2. Jere R. Behrman & Flávio Cunha & Esteban Puentes & Fan Wang, 2018. "You Are What Your Parents Expect: Height and Local Reference Points," PIER Working Paper Archive 18-007, Penn Institute for Economic Research, Department of Economics, University of Pennsylvania, revised 01 Apr 2022.
    3. Katherine Carbeck & Peter Arcese & Irby Lovette & Christin Pruett & Kevin Winker & Jennifer Walsh, 2023. "Candidate genes under selection in song sparrows co-vary with climate and body mass in support of Bergmann’s Rule," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Jonathan D. Herman & Chuangqi Wang & Carolin Loos & Hyunah Yoon & Johanna Rivera & M. Eugenia Dieterle & Denise Haslwanter & Rohit K. Jangra & Robert H. Bortz & Katharine J. Bar & Boris Julg & Kartik , 2021. "Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    5. Peter K Hatemi & Enda Byrne & Rose McDermott, 2012. "Introduction: What is a ‘gene’ and why does it matter for political science?," Journal of Theoretical Politics, , vol. 24(3), pages 305-327, July.
    6. Shujuan Zhao & Kedous Y. Mekbib & Martijn A. Ent & Garrett Allington & Andrew Prendergast & Jocelyn E. Chau & Hannah Smith & John Shohfi & Jack Ocken & Daniel Duran & Charuta G. Furey & Le Thi Hao & P, 2023. "Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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