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Genetics, pathogenesis and clinical interventions in type 1 diabetes

Author

Listed:
  • Jeffrey A. Bluestone

    (University of California, San Francisco, San Francisco, California 94143, USA)

  • Kevan Herold

    (Yale University, New Haven, Connecticut 06520, USA)

  • George Eisenbarth

    (Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045-6511, USA)

Abstract

Understanding diabetes The clinical picture of type 1 diabetes — a progressive loss of pancreatic β-cell function and a requirement for daily insulin treatment — has been apparent for over a century but the precise nature of the disease progression continues to emerge. Recent progress towards understanding the pathogenetics and genetics of diabetes has been rapid, thanks to extensive research in rodent models and in diabetes patients. A review by Jeffrey Bluestone, Kevan Herold and George Eisenbarth recaps some of the major developments of the past decade and reports on the exciting new clinical interventions that are now being tested, some with the potential to be adapted for use in autoimmune diseases other than diabetes.

Suggested Citation

  • Jeffrey A. Bluestone & Kevan Herold & George Eisenbarth, 2010. "Genetics, pathogenesis and clinical interventions in type 1 diabetes," Nature, Nature, vol. 464(7293), pages 1293-1300, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08933
    DOI: 10.1038/nature08933
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    Cited by:

    1. Thompson, Owen, 2014. "Genetic mechanisms in the intergenerational transmission of health," Journal of Health Economics, Elsevier, vol. 35(C), pages 132-146.
    2. Ruikun Cai & Zexian Liu & Jian Ren & Chuang Ma & Tianshun Gao & Yanhong Zhou & Qing Yang & Yu Xue, 2012. "GPS-MBA: Computational Analysis of MHC Class II Epitopes in Type 1 Diabetes," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-9, March.

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