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Memory CD8 T-cell compartment grows in size with immunological experience

Author

Listed:
  • Vaiva Vezys

    (University of Minnesota, Minneapolis, Minnesota 55455, USA
    Emory Vaccine Center, Emory University School of Medicine, and,)

  • Andrew Yates

    (Emory University, Atlanta, Georgia 30322, USA)

  • Kerry A. Casey

    (University of Minnesota, Minneapolis, Minnesota 55455, USA)

  • Gibson Lanier

    (Emory Vaccine Center, Emory University School of Medicine, and,)

  • Rafi Ahmed

    (Emory Vaccine Center, Emory University School of Medicine, and,)

  • Rustom Antia

    (Emory University, Atlanta, Georgia 30322, USA)

  • David Masopust

    (University of Minnesota, Minneapolis, Minnesota 55455, USA
    Emory Vaccine Center, Emory University School of Medicine, and,)

Abstract

Gaining from the experience Repeated exposure to pathogens and the generation of memory CD8+ T cells tasked to kill that pathogen is thought to result in attrition of the pre-existing memory T cell pool to keep the overall size of the memory compartment constant. But new work in mice shows that the size of the memory CD8+ T-cell compartment increases after immunization, and that the generation of new memory CD8+ T cells does not significantly reduce the number of pre-existing memory CD8+ T cells. The discovery that the number of CD8+ T-cell cells in the mammalian host can adapt according to immunological experience could be important for the production of vaccines, since it may be possible to induce specific immune responses that require a high frequency of CD8+ T cells without impairing pre-existing immunities to other infections.

Suggested Citation

  • Vaiva Vezys & Andrew Yates & Kerry A. Casey & Gibson Lanier & Rafi Ahmed & Rustom Antia & David Masopust, 2009. "Memory CD8 T-cell compartment grows in size with immunological experience," Nature, Nature, vol. 457(7226), pages 196-199, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7226:d:10.1038_nature07486
    DOI: 10.1038/nature07486
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    Cited by:

    1. Alina Lelic & Chris P Verschoor & Mario Ventresca & Robin Parsons & Carole Evelegh & Dawn Bowdish & Michael R Betts & Mark B Loeb & Jonathan L Bramson, 2012. "The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age," PLOS Pathogens, Public Library of Science, vol. 8(12), pages 1-11, December.

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