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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Author

Listed:
  • Libor Macůrek

    (University Medical Center Utrecht)

  • Arne Lindqvist

    (University Medical Center Utrecht)

  • Dan Lim

    (Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Michael A. Lampson

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104-6069, USA)

  • Rob Klompmaker

    (University Medical Center Utrecht)

  • Raimundo Freire

    (Unidad de Investigación, Hospital Universitario de Canarias)

  • Christophe Clouin

    (Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Stephen S. Taylor

    (Faculty of Life Sciences, University of Manchester)

  • Michael B. Yaffe

    (Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • René H. Medema

    (University Medical Center Utrecht)

Abstract

Cell division: PLK1 and aurora A at the checkpoint Polo-like kinase-1 (PLK1) is an essential mitotic kinase regulating multiple aspects of the cell division process. Here, activation of PLK1 is shown to occur before mitosis and to depend on phosphorylation by aurora-A kinase, facilitated by a cofactor Bora. The initial activation of PLK1 seems to be a primary function of aurora-A.

Suggested Citation

  • Libor Macůrek & Arne Lindqvist & Dan Lim & Michael A. Lampson & Rob Klompmaker & Raimundo Freire & Christophe Clouin & Stephen S. Taylor & Michael B. Yaffe & René H. Medema, 2008. "Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery," Nature, Nature, vol. 455(7209), pages 119-123, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7209:d:10.1038_nature07185
    DOI: 10.1038/nature07185
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