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A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi

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  • Anastasios D. Tsaousis

    (Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Framlington Place, Newcastle University
    School of Biology, Devonshire Building, Newcastle University)

  • Edmund R. S. Kunji

    (The Dunn Human Nutrition Unit, Medical Research Council, Cambridge CB2 2XY, UK)

  • Alina V. Goldberg

    (Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Framlington Place, Newcastle University)

  • John M. Lucocq

    (School of Life Sciences, WTB/MSI complex, University of Dundee)

  • Robert P. Hirt

    (Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Framlington Place, Newcastle University)

  • T. Martin Embley

    (Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Framlington Place, Newcastle University)

Abstract

Life without mitochondria: Microsporidia 'borrow' their ATP The micosporidia, including the parasite Encephalitozoon cuniculi that is an opportunistic pathogen in humans, have undergone extreme genomic and cellular reduction. Instead of mitochondria, they contain remnant organelles known as mitosomes. Somehow, these organisms need to get hold of ATP, and now there is evidence that E. cuniculi uses bacterial-like transport proteins to 'steal' ATP from the cytosol of its eukaryotic host.

Suggested Citation

  • Anastasios D. Tsaousis & Edmund R. S. Kunji & Alina V. Goldberg & John M. Lucocq & Robert P. Hirt & T. Martin Embley, 2008. "A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi," Nature, Nature, vol. 453(7194), pages 553-556, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06903
    DOI: 10.1038/nature06903
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    Cited by:

    1. Pavel Dolezal & Michael J Dagley & Maya Kono & Peter Wolynec & Vladimir A Likić & Jung Hock Foo & Miroslava Sedinová & Jan Tachezy & Anna Bachmann & Iris Bruchhaus & Trevor Lithgow, 2010. "The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica," PLOS Pathogens, Public Library of Science, vol. 6(3), pages 1-13, March.
    2. Xiaojian Shi & Bryn Reinstadler & Hardik Shah & Tsz-Leung To & Katie Byrne & Luanna Summer & Sarah E. Calvo & Olga Goldberger & John G. Doench & Vamsi K. Mootha & Hongying Shen, 2022. "Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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