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REST maintains self-renewal and pluripotency of embryonic stem cells

Author

Listed:
  • Sanjay K. Singh

    (Department of Cancer Genetics,
    Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA)

  • Mohamedi N. Kagalwala

    (Department of Cancer Genetics,
    Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Present address: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA.)

  • Jan Parker-Thornburg

    (Department of Biochemistry and Molecular Biology,)

  • Henry Adams

    (Department of Cancer Genetics,)

  • Sadhan Majumder

    (Department of Cancer Genetics,
    Department of Neuro-Oncology,
    The Brain Tumor Center,
    Center for Stem Cell and Developmental Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA)

Abstract

The neuronal repressor protein REST (also known as NRSF) maintains self renewal and pluripotency in embryonic stem cells through suppression of the miRNA-21, and is therefore a newly identified member of the transcriptional network maintaining stem cells in a pluripotent state. Knocking down its activity by using of siRNA or deletion of one allele caused loss of self renewal and led the cells to express differentiated markers.

Suggested Citation

  • Sanjay K. Singh & Mohamedi N. Kagalwala & Jan Parker-Thornburg & Henry Adams & Sadhan Majumder, 2008. "REST maintains self-renewal and pluripotency of embryonic stem cells," Nature, Nature, vol. 453(7192), pages 223-227, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7192:d:10.1038_nature06863
    DOI: 10.1038/nature06863
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    Cited by:

    1. Vazquez-Zapien GJ & Mata-Miranda MM & Guerrero-Robles CI & Sanchez-Monroy V & Lozano-Trenado LM & Gonzalez-Diaz CA, 2017. "Electrical Bioimpedance Spectroscopy as Biosensor Technique to Identify Pluripotent Stem Cells and Fibroblasts," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 3(2), pages 30-35, September.

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