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A skin microRNA promotes differentiation by repressing ‘stemness’

Author

Listed:
  • Rui Yi

    (Howard Hughes Medical Institute, and,
    Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York City, New York 10065, USA)

  • Matthew N. Poy

    (Swiss Federal Institute of Technology ETH Zurich, Institute of Molecular Systems Biology)

  • Markus Stoffel

    (Swiss Federal Institute of Technology ETH Zurich, Institute of Molecular Systems Biology)

  • Elaine Fuchs

    (Howard Hughes Medical Institute, and,
    Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York City, New York 10065, USA)

Abstract

An RNA to block 'stemness' Epithelial tissues such as the skin are able to self-renew, thanks to the stem cells located in a basal layer. Cells originating from these stem cells differentiate — losing the ability to proliferate — as they grow towards the tissue surface. Now a microRNA has been linked to this process of stratification and differentiation. miR-203 is not expressed in epidermal stem cells, but it is made as cells commit to differentiate. It represses the cell's 'stemness' and enforces differentiation by suppressing the production of p63, a protein that is known to regulate stem cell maintenance in skin.

Suggested Citation

  • Rui Yi & Matthew N. Poy & Markus Stoffel & Elaine Fuchs, 2008. "A skin microRNA promotes differentiation by repressing ‘stemness’," Nature, Nature, vol. 452(7184), pages 225-229, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7184:d:10.1038_nature06642
    DOI: 10.1038/nature06642
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    Cited by:

    1. Fang Yan & Haihong Liu & Junjun Hao & Zengrong Liu, 2012. "Dynamical Behaviors of Rb-E2F Pathway Including Negative Feedback Loops Involving miR449," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-13, September.

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