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Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Author

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  • Benjamin L. Ebert

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jennifer Pretz

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Jocelyn Bosco

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Cindy Y. Chang

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Pablo Tamayo

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Naomi Galili

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA)

  • Azra Raza

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA)

  • David E. Root

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Eyal Attar

    (Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Steven R. Ellis

    (University of Louisville)

  • Todd R. Golub

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA)

Abstract

Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient tumour suppressor genes identifies RPS14, which regulates ribosomal RNA processing as a candidate tumour suppressor gene responsible for this so-called 5q− syndrome.

Suggested Citation

  • Benjamin L. Ebert & Jennifer Pretz & Jocelyn Bosco & Cindy Y. Chang & Pablo Tamayo & Naomi Galili & Azra Raza & David E. Root & Eyal Attar & Steven R. Ellis & Todd R. Golub, 2008. "Identification of RPS14 as a 5q- syndrome gene by RNA interference screen," Nature, Nature, vol. 451(7176), pages 335-339, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06494
    DOI: 10.1038/nature06494
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    Cited by:

    1. Kiran N Meekings & Jeremy Leipzig & Frederic D Bushman & Graham P Taylor & Charles R M Bangham, 2008. "HTLV-1 Integration into Transcriptionally Active Genomic Regions Is Associated with Proviral Expression and with HAM/TSP," PLOS Pathogens, Public Library of Science, vol. 4(3), pages 1-10, March.

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