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Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

Author

Listed:
  • S. K. Reddy

    (Harvard Medical School, and
    Boston, Massachusetts 02115, USA)

  • M. Rape

    (Harvard Medical School, and
    Present address: Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3202, USA.)

  • W. A. Margansky

    (Harvard Medical School, and)

  • M. W. Kirschner

    (Harvard Medical School, and)

Abstract

Cell division control During cell division the spindle checkpoint ensures that chromosome segregation is delayed until all chromosomes are properly attached to the mitotic spindle. Two papers now identify a new regulatory mechanism that controls the spindle checkpoint. This involves the fine-tuned ubiquitination and de-ubiquitination of a coactivator of the anaphase promoting complex APC/C to regulate the timing of APC/C activation and thereby the onset of anaphase.

Suggested Citation

  • S. K. Reddy & M. Rape & W. A. Margansky & M. W. Kirschner, 2007. "Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation," Nature, Nature, vol. 446(7138), pages 921-925, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7138:d:10.1038_nature05734
    DOI: 10.1038/nature05734
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    Cited by:

    1. Cheng-Jie Zhou & Xing-Yue Wang & Yan-Hua Dong & Dong-Hui Wang & Zhe Han & Xiao-Jie Zhang & Qing-Yuan Sun & John Carroll & Cheng-Guang Liang, 2022. "CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Marco Simonetta & Romilde Manzoni & Roberto Mosca & Marina Mapelli & Lucia Massimiliano & Martin Vink & Bela Novak & Andrea Musacchio & Andrea Ciliberto, 2009. "The Influence of Catalysis on Mad2 Activation Dynamics," PLOS Biology, Public Library of Science, vol. 7(1), pages 1-14, January.

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