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Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein

Author

Listed:
  • Changjiang Dong

    (The University of St Andrews)

  • Konstantinos Beis

    (The University of St Andrews
    Imperial College of Science)

  • Jutta Nesper

    (The University of Guelph
    University of Konstanz)

  • Anne L. Brunkan-LaMontagne

    (The University of Guelph)

  • Bradley R. Clarke

    (The University of Guelph)

  • Chris Whitfield

    (The University of Guelph)

  • James H. Naismith

    (The University of St Andrews)

Abstract

Wza matter Many bacteria possess an external polysaccharide 'capsule' that helps them evade the host immune system and colonize surfaces. As a point of contact between host and pathogen, the capsule is a potential target for vaccines and other therapies. The three-dimensional structure of Wza, a protein responsible for exporting a capsular polysaccharide in Escherichia coli, has now been determined. Most of the protein is located in the periplasm, the space between the inner plasma membrane and the outer cellular membrane, and the protein contains a large central cavity through which the polysaccharide is transported.

Suggested Citation

  • Changjiang Dong & Konstantinos Beis & Jutta Nesper & Anne L. Brunkan-LaMontagne & Bradley R. Clarke & Chris Whitfield & James H. Naismith, 2006. "Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein," Nature, Nature, vol. 444(7116), pages 226-229, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7116:d:10.1038_nature05267
    DOI: 10.1038/nature05267
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    Cited by:

    1. Smrithi Krishnan R & Kalyanashis Jana & Amina H. Shaji & Karthika S. Nair & Anjali Devi Das & Devika Vikraman & Harsha Bajaj & Ulrich Kleinekathöfer & Kozhinjampara R. Mahendran, 2022. "Assembly of transmembrane pores from mirror-image peptides," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Salim T Islam & Israel Vergara Alvarez & Fares Saïdi & Annick Guiseppi & Evgeny Vinogradov & Gaurav Sharma & Leon Espinosa & Castrese Morrone & Gael Brasseur & Jean-François Guillemot & Anaïs Benarouc, 2020. "Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion," PLOS Biology, Public Library of Science, vol. 18(6), pages 1-31, June.

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