IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v441y2006i7092d10.1038_nature04871.html
   My bibliography  Save this article

Hypoxia signalling in cancer and approaches to enforce tumour regression

Author

Listed:
  • Jacques Pouysségur

    (Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne)

  • Frédéric Dayan

    (Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne)

  • Nathalie M. Mazure

    (Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne)

Abstract

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread. This pleiotropic action is orchestrated by hypoxia-inducible factor (HIF), which is a master transcriptional factor in nutrient stress signalling. Understanding the role of HIF in intracellular pH (pHi) regulation, metabolism, cell invasion, autophagy and cell death is crucial for developing novel anticancer therapies. There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pHi-control systems.

Suggested Citation

  • Jacques Pouysségur & Frédéric Dayan & Nathalie M. Mazure, 2006. "Hypoxia signalling in cancer and approaches to enforce tumour regression," Nature, Nature, vol. 441(7092), pages 437-443, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7092:d:10.1038_nature04871
    DOI: 10.1038/nature04871
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04871
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04871?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Akikazu Harada & Yoshiaki Yasumizu & Takeshi Harada & Katsumi Fumoto & Akira Sato & Natsumi Maehara & Ryota Sada & Shinji Matsumoto & Takashi Nishina & Kiyoshi Takeda & Eiichi Morii & Hisako Kayama & , 2025. "Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression," Nature Communications, Nature, vol. 16(1), pages 1-24, December.
    2. Md Harun-Or-Roshid & Md Borqat Ali & Jesmin & Md Nurul Haque Mollah, 2022. "Association of hypoxia inducible factor 1-Alpha gene polymorphisms with multiple disease risks: A comprehensive meta-analysis," PLOS ONE, Public Library of Science, vol. 17(8), pages 1-23, August.
    3. Nagarekha Pasupuleti & Anthony Valenzuela & Yamini Manohar & Sundeep Dugar & Jann Sarkaria, 2018. "Intracellular Urokinase uPA-PAI-1 Complex: Disruption by Small Molecule Targets Hypoxically Programmed Glioma Cells," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 7(3), pages 42-59, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:441:y:2006:i:7092:d:10.1038_nature04871. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.