Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression
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DOI: 10.1038/s41467-025-58748-9
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- James A. Stefater III & Ian Lewkowich & Sujata Rao & Giovanni Mariggi & April C. Carpenter & Adam R. Burr & Jieqing Fan & Rieko Ajima & Jeffery D. Molkentin & Bart O. Williams & Marsha Wills-Karp & Je, 2011. "Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells," Nature, Nature, vol. 474(7352), pages 511-515, June.
- Han Luo & Xuyang Xia & Li-Bin Huang & Hyunsu An & Minyuan Cao & Gyeong Dae Kim & Hai-Ning Chen & Wei-Han Zhang & Yang Shu & Xiangyu Kong & Zhixiang Ren & Pei-Heng Li & Yang Liu & Huairong Tang & Rongh, 2022. "Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Bianca Dumitrascu & Soledad Villar & Dustin G. Mixon & Barbara E. Engelhardt, 2021. "Optimal marker gene selection for cell type discrimination in single cell analyses," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
- Takashi Nishina & Yutaka Deguchi & Daisuke Ohshima & Wakami Takeda & Masato Ohtsuka & Shigeyuki Shichino & Satoshi Ueha & Soh Yamazaki & Mika Kawauchi & Eri Nakamura & Chiharu Nishiyama & Yuko Kojima , 2021. "Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
- Jacques Pouysségur & Frédéric Dayan & Nathalie M. Mazure, 2006. "Hypoxia signalling in cancer and approaches to enforce tumour regression," Nature, Nature, vol. 441(7092), pages 437-443, May.
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