IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v435y2005i7043d10.1038_nature03702.html
   My bibliography  Save this article

MicroRNA expression profiles classify human cancers

Author

Listed:
  • Jun Lu

    (Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute and Harvard Medical School)

  • Gad Getz

    (Broad Institute of MIT and Harvard)

  • Eric A. Miska

    (Massachusetts Institute of Technology
    University of Cambridge)

  • Ezequiel Alvarez-Saavedra

    (Massachusetts Institute of Technology)

  • Justin Lamb

    (Broad Institute of MIT and Harvard)

  • David Peck

    (Broad Institute of MIT and Harvard)

  • Alejandro Sweet-Cordero

    (MIT Center for Cancer Research
    Dana-Farber Cancer Institute and Harvard Medical School)

  • Benjamin L. Ebert

    (Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute and Harvard Medical School)

  • Raymond H. Mak

    (Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute and Harvard Medical School)

  • Adolfo A. Ferrando

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • James R. Downing

    (St. Jude Children's Research Hospital)

  • Tyler Jacks

    (Massachusetts Institute of Technology
    MIT Center for Cancer Research)

  • H. Robert Horvitz

    (Massachusetts Institute of Technology
    Harvard Medical School)

  • Todd R. Golub

    (Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute and Harvard Medical School
    Harvard Medical School)

Abstract

MicroRNA in cancer MicroRNAs are regulatory, non-coding RNAs about 22 nucleotides in length: over 200 have been identified in humans, and their functions are beginning to be pinned down. It has been suggested that like other regulatory molecules they might be involved in tumour formation, and three papers in this issue confirm that this is the case. One cluster of microRNAs, known as mir-17–92, is shown to be a potential oncogene by its action in an in vivo model of human B-cell lymphoma. A cluster of microRNAs on human chromosome 13 has been found to be regulated by c-Myc, an important transcription factor that is overexpressed in many human cancers. And analysis of microRNA expression in over 300 individuals shows that microRNA profiles could be of value in cancer diagnosis. There is a global downregulation of microRNA in tumours, and the microRNA profile also reflects the origin and differentiation state of the tumours.

Suggested Citation

  • Jun Lu & Gad Getz & Eric A. Miska & Ezequiel Alvarez-Saavedra & Justin Lamb & David Peck & Alejandro Sweet-Cordero & Benjamin L. Ebert & Raymond H. Mak & Adolfo A. Ferrando & James R. Downing & Tyler , 2005. "MicroRNA expression profiles classify human cancers," Nature, Nature, vol. 435(7043), pages 834-838, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7043:d:10.1038_nature03702
    DOI: 10.1038/nature03702
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature03702
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature03702?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yun Xiao & Chaohan Xu & Jinxia Guan & Yanyan Ping & Huihui Fan & Yiqun Li & Hongying Zhao & Xia Li, 2012. "Discovering Dysfunction of Multiple MicroRNAs Cooperation in Disease by a Conserved MicroRNA Co-Expression Network," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-11, February.
    2. Daniel G Weber & Georg Johnen & Oleksandr Bryk & Karl-Heinz Jöckel & Thomas Brüning, 2012. "Identification of miRNA-103 in the Cellular Fraction of Human Peripheral Blood as a Potential Biomarker for Malignant Mesothelioma – A Pilot Study," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-9, January.
    3. Poonam Kataria & Neha Surela & Amrendra Chaudhary & Jyoti Das, 2022. "MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection," IJERPH, MDPI, vol. 19(4), pages 1-11, February.
    4. Shubin W Shahab & Lilya V Matyunina & Roman Mezencev & L DeEtte Walker & Nathan J Bowen & Benedict B Benigno & John F McDonald, 2011. "Evidence for the Complexity of MicroRNA-Mediated Regulation in Ovarian Cancer: A Systems Approach," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-12, July.
    5. Jian Zhang & Charing C N Chong & George G Chen & Paul B S Lai, 2015. "A Seven-microRNA Expression Signature Predicts Survival in Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-15, June.
    6. Ping Xuan & Ke Han & Maozu Guo & Yahong Guo & Jinbao Li & Jian Ding & Yong Liu & Qiguo Dai & Jin Li & Zhixia Teng & Yufei Huang, 2013. "Prediction of microRNAs Associated with Human Diseases Based on Weighted k Most Similar Neighbors," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-15, August.
    7. Ya-Hui Huang & Kwang-Huei Lin & Hua-Chien Chen & Ming-Ling Chang & Chao-Wei Hsu & Ming-Wei Lai & Tse-Ching Chen & Wei-Chen Lee & Yi-Hsin Tseng & Chau-Ting Yeh, 2012. "Identification of Postoperative Prognostic MicroRNA Predictors in Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-10, May.
    8. Ander Muniategui & Rubén Nogales-Cadenas & Miguél Vázquez & Xabier L. Aranguren & Xabier Agirre & Aernout Luttun & Felipe Prosper & Alberto Pascual-Montano & Angel Rubio, 2012. "Quantification of miRNA-mRNA Interactions," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-10, February.
    9. Ming-yang Song & Kai-feng Pan & Hui-juan Su & Lian Zhang & Jun-ling Ma & Ji-you Li & Yasuhito Yuasa & Daehee Kang & Yong Sung Kim & Wei-cheng You, 2012. "Identification of Serum MicroRNAs as Novel Non-Invasive Biomarkers for Early Detection of Gastric Cancer," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-9, March.
    10. Shib Sankar Bhowmick & Indrajit Saha & Debotosh Bhattacharjee & Loredana M Genovese & Filippo Geraci, 2018. "Genome-wide analysis of NGS data to compile cancer-specific panels of miRNA biomarkers," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-23, July.
    11. Roy Navon & Hui Wang & Israel Steinfeld & Anya Tsalenko & Amir Ben-Dor & Zohar Yakhini, 2009. "Novel Rank-Based Statistical Methods Reveal MicroRNAs with Differential Expression in Multiple Cancer Types," PLOS ONE, Public Library of Science, vol. 4(11), pages 1-10, November.
    12. Wei Meng & Joseph P McElroy & Stefano Volinia & Jeff Palatini & Sarah Warner & Leona W Ayers & Kamalakannan Palanichamy & Arnab Chakravarti & Tim Lautenschlaeger, 2013. "Comparison of MicroRNA Deep Sequencing of Matched Formalin-Fixed Paraffin-Embedded and Fresh Frozen Cancer Tissues," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-9, May.
    13. Xiao Pin Ma & Ting Zhang & Bo Peng & Long Yu & De Ke Jiang, 2013. "Association between microRNA Polymorphisms and Cancer Risk Based on the Findings of 66 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    14. Yunke Song & Duncan Kilburn & Jee Hoon Song & Yulan Cheng & Christopher T Saeui & Douglas G Cheung & Carlo M Croce & Kevin J Yarema & Stephen J Meltzer & Kelvin J Liu & Tza-Huei Wang, 2017. "Determination of absolute expression profiles using multiplexed miRNA analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-18, July.
    15. Jain Yashita & Ding Shanshan & Qiu Jing, 2019. "Sliced inverse regression for integrative multi-omics data analysis," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 18(1), pages 1-13, February.
    16. Maarten Neerincx & Dennis Poel & Daoud L S Sie & Nicole C T van Grieken & Ram C Shankaraiah & Floor S W van der Wolf - de Lijster & Jan-Hein T M van Waesberghe & Jan-Dirk Burggraaf & Paul P Eijk & Cor, 2018. "Combination of a six microRNA expression profile with four clinicopathological factors for response prediction of systemic treatment in patients with advanced colorectal cancer," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-20, August.
    17. Hai-Tao Zhu & Qiong-Zhu Dong & Yuan-Yuan Sheng & Jin-Wang Wei & Guan Wang & Hai-Jun Zhou & Ning Ren & Hu-Liang Jia & Qing-Hai Ye & Lun-Xiu Qin, 2012. "MicroRNA-29a-5p Is a Novel Predictor for Early Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma after Surgical Resection," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
    18. Chen, Albert Y. & Yu, Ting-Yi, 2016. "Network based temporary facility location for the Emergency Medical Services considering the disaster induced demand and the transportation infrastructure in disaster response," Transportation Research Part B: Methodological, Elsevier, vol. 91(C), pages 408-423.
    19. Julia E. Rager & Rebecca C. Fry, 2012. "The Aryl Hydrocarbon Receptor Pathway: A Key Component of the microRNA-Mediated AML Signalisome," IJERPH, MDPI, vol. 9(5), pages 1-15, May.
    20. Rao Youlan & Lee Yoonkyung & Jarjoura David & Ruppert Amy S & Liu Chang-gong & Hsu Jason C & Hagan John P, 2008. "A Comparison of Normalization Techniques for MicroRNA Microarray Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 7(1), pages 1-20, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:435:y:2005:i:7043:d:10.1038_nature03702. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.