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Biochemistry and molecular cell biology of diabetic complications

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  • Michael Brownlee

    (Albert Einstein College of Medicine)

Abstract

Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

Suggested Citation

  • Michael Brownlee, 2001. "Biochemistry and molecular cell biology of diabetic complications," Nature, Nature, vol. 414(6865), pages 813-820, December.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6865:d:10.1038_414813a
    DOI: 10.1038/414813a
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    Cited by:

    1. Nuria Martinez & Lorissa J. Smulan & Michael L. Jameson & Clare M. Smith & Kelly Cavallo & Michelle Bellerose & John Williams & Kim West & Christopher M. Sassetti & Amit Singhal & Hardy Kornfeld, 2023. "Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Daryl I Smith & Hai T Tran, 2018. "Hemodynamic Considerations in the Pathophysiology of Diabetic Peripheral Neuropathy," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 5(5), pages 92-97, February.
    3. Jian-bin Su & Xiao-hua Yang & Xiu-lin Zhang & Hong-li Cai & Hai-yan Huang & Li-hua Zhao & Feng Xu & Tong Chen & Xing-bo Cheng & Xue-qin Wang & Yan Lu, 2017. "The association of long-term glycaemic variability versus sustained chronic hyperglycaemia with heart rate-corrected QT interval in patients with type 2 diabetes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-12, August.
    4. M Usman & AS Qureshi & MZ Ali & Z Umer & MK Ateeq & A Sarfraz & M Hussain & FR Anjum & N Mahmood & M Fakhar-I-Adil & S Umer & H Zhu, 2020. "The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 65(1), pages 25-35.
    5. Meng-Wei Chang & Chun-Ying Huang & Hang-Tsung Liu & Yi-Chun Chen & Ching-Hua Hsieh, 2018. "Stress-Induced and Diabetic Hyperglycemia Associated with Higher Mortality among Intensive Care Unit Trauma Patients: Cross-Sectional Analysis of the Propensity Score-Matched Population," IJERPH, MDPI, vol. 15(5), pages 1-10, May.
    6. Jhauharotul Muchlisyiyah & Rosnah Shamsudin & Roseliza Kadir Basha & Radhiah Shukri & Syahmeer How & Keshavan Niranjan & Daniel Onwude, 2023. "Parboiled Rice Processing Method, Rice Quality, Health Benefits, Environment, and Future Perspectives: A Review," Agriculture, MDPI, vol. 13(7), pages 1-24, July.
    7. Daryl I Smith & Hai T Tran, 2018. "Hemodynamic Considerations in the Pathophysiology of Diabetic Peripheral Neuropathy," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 5(5), pages 1-6, February.

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