IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v411y2001i6835d10.1038_35077213.html
   My bibliography  Save this article

Proliferation, cell cycle and apoptosis in cancer

Author

Listed:
  • Gerard I. Evan

    (UCSF Cancer Center)

  • Karen H. Vousden

    (NCI at Frederick)

Abstract

Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.

Suggested Citation

  • Gerard I. Evan & Karen H. Vousden, 2001. "Proliferation, cell cycle and apoptosis in cancer," Nature, Nature, vol. 411(6835), pages 342-348, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077213
    DOI: 10.1038/35077213
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35077213
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35077213?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sukanya Panja & Mihai Ioan Truica & Christina Y. Yu & Vamshi Saggurthi & Michael W. Craige & Katie Whitehead & Mayra V. Tuiche & Aymen Al-Saadi & Riddhi Vyas & Shridar Ganesan & Suril Gohel & Frederic, 2024. "Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. W. Frank Lenoir & Micaela Morgado & Peter C. DeWeirdt & Megan McLaughlin & Audrey L. Griffith & Annabel K. Sangree & Marissa N. Feeley & Nazanin Esmaeili Anvar & Eiru Kim & Lori L. Bertolet & Medina C, 2021. "Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Jae-Woong Min & Woo Jin Kim & Jeong A Han & Yu-Jin Jung & Kyu-Tae Kim & Woong-Yang Park & Hae-Ock Lee & Sun Shim Choi, 2015. "Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    4. Neha Pal & Shalini Rathore & Priya Kaushik & Swati Tyagi & Abhimanyu Kumar Jha & Anshuman Kumar, 2019. "Promoter Hypermethylation of Apoptotic genes in Oral Squamous Cell Carcinoma," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 13(5), pages 103-108, May.
    5. Menchón, S.A. & Condat, C.A., 2011. "Quiescent cells: A natural way to resist chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 390(20), pages 3354-3361.
    6. Anthony Szedlak & Spencer Sims & Nicholas Smith & Giovanni Paternostro & Carlo Piermarocchi, 2017. "Cell cycle time series gene expression data encoded as cyclic attractors in Hopfield systems," PLOS Computational Biology, Public Library of Science, vol. 13(11), pages 1-19, November.
    7. Yongzhi Yang & Feng Wang & Chenzhang Shi & Yang Zou & Huanlong Qin & Yanlei Ma, 2012. "Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-9, May.
    8. Lei Xu & Xin Zhou & Feng Jiang & Man-Tang Qiu & Zhi Zhang & Rong Yin & Lin Xu, 2013. "FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-9, September.
    9. David A Knowles & Gina Bouchard & Sylvia Plevritis, 2019. "Sparse discriminative latent characteristics for predicting cancer drug sensitivity from genomic features," PLOS Computational Biology, Public Library of Science, vol. 15(5), pages 1-18, May.
    10. Song Zhang & Qianyi Xiao & Zhuqing Shi & Guopeng Yu & Xiao-Pin Ma & Haitao Chen & Pengyin Zhang & Suqin Shen & He-Xi Ge Sai-Yin & Tao-Yang Chen & Pei-Xin Lu & Neng-Jin Wang & Weihua Ren & Peng Huang &, 2017. "Caspase polymorphisms and prognosis of hepatocellular carcinoma," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    11. Zhou Zhong-Xing & Mi Yuan-Yuan & Ma Hai Zhen & Zou Jian-Gang & Zhang Li-Feng, 2013. "FAS-1377 G/A (rs2234767) Polymorphism and Cancer Susceptibility: A Meta-Analysis of 17,858 Cases and 24,311 Controls," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    12. Yi Fu & Robert Kunz & Jianhua Wu & Cheng Dong, 2012. "Study of Local Hydrodynamic Environment in Cell-Substrate Adhesion Using Side-View μPIV Technology," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-13, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077213. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.