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Vascular-specific growth factors and blood vessel formation

Author

Listed:
  • George D. Yancopoulos

    (Regeneron Pharmaceuticals, Inc)

  • Samuel Davis

    (Regeneron Pharmaceuticals, Inc)

  • Nicholas W. Gale

    (Regeneron Pharmaceuticals, Inc)

  • John S. Rudge

    (Regeneron Pharmaceuticals, Inc)

  • Stanley J. Wiegand

    (Regeneron Pharmaceuticals, Inc)

  • Jocelyn Holash

    (Regeneron Pharmaceuticals, Inc)

Abstract

A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.

Suggested Citation

  • George D. Yancopoulos & Samuel Davis & Nicholas W. Gale & John S. Rudge & Stanley J. Wiegand & Jocelyn Holash, 2000. "Vascular-specific growth factors and blood vessel formation," Nature, Nature, vol. 407(6801), pages 242-248, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6801:d:10.1038_35025215
    DOI: 10.1038/35025215
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    Cited by:

    1. Gianna Maria Nardi & Elisabetta Ferrara & Ilaria Converti & Francesca Cesarano & Salvatore Scacco & Roberta Grassi & Antonio Gnoni & Felice Roberto Grassi & Biagio Rapone, 2020. "Does Diabetes Induce the Vascular Endothelial Growth Factor (VEGF) Expression in Periodontal Tissues? A Systematic Review," IJERPH, MDPI, vol. 17(8), pages 1-16, April.
    2. Domanskyi, Sergii & Hakansson, Alex & Meng, Michelle & Pham, Benjamin K & Graff Zivin, Joshua S & Piermarocchi, Carlo & Paternostro, Giovanni & Ferrara, Napoleone, 2022. "Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells," University of California at San Diego, Economics Working Paper Series qt7rx412x7, Department of Economics, UC San Diego.
    3. Balkrishna Chaube & Kathryn M. Citrin & Mahnaz Sahraei & Abhishek K. Singh & Diego Saenz Urturi & Wen Ding & Richard W. Pierce & Raaisa Raaisa & Rebecca Cardone & Richard Kibbey & Carlos Fernández-Her, 2023. "Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Anna Goussia & Nafsika Simou & Flora Zagouri & Kyriaki Manousou & Georgios Lazaridis & Helen Gogas & Angelos Koutras & Maria Sotiropoulou & George Pentheroudakis & Dimitrios Bafaloukos & Christos Mark, 2018. "Associations of angiogenesis-related proteins with specific prognostic factors, breast cancer subtypes and survival outcome in early-stage breast cancer patients. A Hellenic Cooperative Oncology Group," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-19, July.

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