IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v386y1997i6625d10.1038_386569a0.html
   My bibliography  Save this article

Transcriptional activation by recruitment

Author

Listed:
  • Mark Ptashne

    (Harvard University)

  • Alexander Gann

    (Lancaster University)

Abstract

The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

Suggested Citation

  • Mark Ptashne & Alexander Gann, 1997. "Transcriptional activation by recruitment," Nature, Nature, vol. 386(6625), pages 569-577, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6625:d:10.1038_386569a0
    DOI: 10.1038/386569a0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/386569a0
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/386569a0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Till D Frank & Aimée M Carmody & Boris N Kholodenko, 2012. "Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-15, April.
    2. Ying Liang & Haiyue Xu & Tao Cheng & Yujuan Fu & Hanwei Huang & Wenchang Qian & Junyan Wang & Yuenan Zhou & Pengxu Qian & Yafei Yin & Pengfei Xu & Wei Zou & Baohui Chen, 2022. "Gene activation guided by nascent RNA-bound transcription factors," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Alistair N Boettiger & Peter L Ralph & Steven N Evans, 2011. "Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability," PLOS Computational Biology, Public Library of Science, vol. 7(5), pages 1-14, May.
    4. Krishanpal Anamika & Àkos Gyenis & Laetitia Poidevin & Olivier Poch & Làszlò Tora, 2012. "RNA Polymerase II Pausing Downstream of Core Histone Genes Is Different from Genes Producing Polyadenylated Transcripts," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-14, June.
    5. Miaomiao Li & Tao Yao & Wanru Lin & Will E. Hinckley & Mary Galli & Wellington Muchero & Andrea Gallavotti & Jin-Gui Chen & Shao-shan Carol Huang, 2023. "Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Lala M Motlhabi & Gary D Stormo, 2011. "Assessing the Effects of Symmetry on Motif Discovery and Modeling," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-8, September.
    7. T.J.M. van Dooren, 1998. "The Evolutionary Ecology of Dominance-Recessivity," Working Papers ir98096, International Institute for Applied Systems Analysis.
    8. Michael E Wall & David A Markowitz & Judah L Rosner & Robert G Martin, 2009. "Model of Transcriptional Activation by MarA in Escherichia coli," PLOS Computational Biology, Public Library of Science, vol. 5(12), pages 1-11, December.
    9. Rutger Hermsen & Bas Ursem & Pieter Rein ten Wolde, 2010. "Combinatorial Gene Regulation Using Auto-Regulation," PLOS Computational Biology, Public Library of Science, vol. 6(6), pages 1-13, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:386:y:1997:i:6625:d:10.1038_386569a0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.