Author
Listed:
- Jordi Merino
(Massachusetts General Hospital
Broad Institute of MIT and Harvard
Massachusetts General Hospital
Harvard Medical School)
- Hassan S. Dashti
(Massachusetts General Hospital
Broad Institute of MIT and Harvard
Massachusetts General Hospital and Harvard Medical School)
- Chloé Sarnowski
(Boston University School of Public Health)
- Jacqueline M. Lane
(Massachusetts General Hospital
Broad Institute of MIT and Harvard
Massachusetts General Hospital and Harvard Medical School)
- Petar V. Todorov
(University of Copenhagen)
- Miriam S. Udler
(Massachusetts General Hospital
Broad Institute of MIT and Harvard
Massachusetts General Hospital
Harvard Medical School)
- Yanwei Song
(Massachusetts General Hospital
Broad Institute of MIT and Harvard)
- Heming Wang
(Broad Institute of MIT and Harvard
Brigham and Women’s Hospital
Harvard Medical School)
- Jaegil Kim
(Massachusetts General Hospital)
- Chandler Tucker
(Massachusetts General Hospital)
- John Campbell
(Beth Israel Deaconess Medical Center, Harvard Medical School
University of Virginia)
- Toshiko Tanaka
(National Institute on Aging)
- Audrey Y. Chu
(Merck)
- Linus Tsai
(Beth Israel Deaconess Medical Center, Harvard Medical School)
- Tune H. Pers
(Boston University School of Public Health
Statens Serum Institut)
- Daniel I. Chasman
(Brigham and Women’s Hospital and Harvard Medical School
Brigham and Women’s Hospital and Harvard Medical School)
- Martin K. Rutter
(University of Manchester
Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre)
- Josée Dupuis
(Boston University School of Public Health)
- Jose C. Florez
(Massachusetts General Hospital
Broad Institute of MIT and Harvard
Massachusetts General Hospital
Harvard Medical School)
- Richa Saxena
(Massachusetts General Hospital
Broad Institute of MIT and Harvard
Massachusetts General Hospital and Harvard Medical School
Harvard Medical School)
Abstract
Dietary intake is a major contributor to the global obesity epidemic and represents a complex behavioural phenotype that is partially affected by innate biological differences. Here, we present a multivariate genome-wide association analysis of overall variation in dietary intake to account for the correlation between dietary carbohydrate, fat and protein in 282,271 participants of European ancestry from the UK Biobank (n = 191,157) and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 91,114), and identify 26 distinct genome-wide significant loci. Dietary intake signals map exclusively to specific brain regions and are enriched for genes expressed in specialized subtypes of GABAergic, dopaminergic and glutamatergic neurons. We identified two main clusters of genetic variants for overall variation in dietary intake that were differently associated with obesity and coronary artery disease. These results enhance the biological understanding of interindividual differences in dietary intake by highlighting neural mechanisms, supporting functional follow-up experiments and possibly providing new avenues for the prevention and treatment of prevalent complex metabolic diseases.
Suggested Citation
Jordi Merino & Hassan S. Dashti & Chloé Sarnowski & Jacqueline M. Lane & Petar V. Todorov & Miriam S. Udler & Yanwei Song & Heming Wang & Jaegil Kim & Chandler Tucker & John Campbell & Toshiko Tanaka , 2022.
"Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits,"
Nature Human Behaviour, Nature, vol. 6(1), pages 155-163, January.
Handle:
RePEc:nat:nathum:v:6:y:2022:i:1:d:10.1038_s41562-021-01182-w
DOI: 10.1038/s41562-021-01182-w
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