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Plasmodium co-infection protects against chikungunya virus-induced pathologies

Author

Listed:
  • Teck-Hui Teo

    (Technology and Research (A*STAR))

  • Fok-Moon Lum

    (Technology and Research (A*STAR))

  • Khairunnisa Ghaffar

    (Technology and Research (A*STAR))

  • Yi-Hao Chan

    (Technology and Research (A*STAR)
    National University of Singapore)

  • Siti Naqiah Amrun

    (Technology and Research (A*STAR))

  • Jeslin J. L. Tan

    (Technology and Research (A*STAR))

  • Cheryl Y. P. Lee

    (Technology and Research (A*STAR)
    National University of Singapore)

  • Tze-Kwang Chua

    (Technology and Research (A*STAR))

  • Guillaume Carissimo

    (Technology and Research (A*STAR))

  • Wendy W. L. Lee

    (Technology and Research (A*STAR))

  • Carla Claser

    (Technology and Research (A*STAR))

  • Ravisankar Rajarethinam

    (Technology and Research (A*STAR))

  • Laurent Rénia

    (Technology and Research (A*STAR))

  • Lisa F. P. Ng

    (Technology and Research (A*STAR)
    National University of Singapore
    University of Liverpool)

Abstract

Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFNγ, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation. Conversely, concomitant infection with both pathogens limits the peak of joint inflammation with no effect on CHIKV viraemia. Reduced peak joint inflammation is regulated by elevated apoptosis of CD4+ T-cells in the lymph nodes and disrupted CXCR3-mediated CD4+ T-cell migration that abolishes their infiltration into the joints. Virus clearance from tissues is delayed in both infection scenarios, and is associated with a disruption of B cell affinity-maturation in the spleen that reduces CHIKV-neutralizing antibody production.

Suggested Citation

  • Teck-Hui Teo & Fok-Moon Lum & Khairunnisa Ghaffar & Yi-Hao Chan & Siti Naqiah Amrun & Jeslin J. L. Tan & Cheryl Y. P. Lee & Tze-Kwang Chua & Guillaume Carissimo & Wendy W. L. Lee & Carla Claser & Ravi, 2018. "Plasmodium co-infection protects against chikungunya virus-induced pathologies," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06227-9
    DOI: 10.1038/s41467-018-06227-9
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    Cited by:

    1. Hannah M Edwards & Helen Counihan & Craig Bonnington & Jane Achan & Prudence Hamade & James K Tibenderana, 2021. "The impact of malaria coinfection on Ebola virus disease outcomes: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-27, May.
    2. Alissa R Young & Marissa C Locke & Lindsey E Cook & Bradley E Hiller & Rong Zhang & Matthew L Hedberg & Kristen J Monte & Deborah J Veis & Michael S Diamond & Deborah J Lenschow, 2019. "Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA," PLOS Pathogens, Public Library of Science, vol. 15(8), pages 1-30, August.

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