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Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Author

Listed:
  • Youssef Ezzyat

    (University of Pennsylvania)

  • Paul A. Wanda

    (University of Pennsylvania)

  • Deborah F. Levy

    (University of Pennsylvania)

  • Allison Kadel

    (University of Pennsylvania)

  • Ada Aka

    (University of Pennsylvania)

  • Isaac Pedisich

    (University of Pennsylvania)

  • Michael R. Sperling

    (Thomas Jefferson University Hospital)

  • Ashwini D. Sharan

    (Thomas Jefferson University Hospital)

  • Bradley C. Lega

    (University of Texas, Southwestern)

  • Alexis Burks

    (University of Texas, Southwestern)

  • Robert E. Gross

    (Emory University Hospital)

  • Cory S. Inman

    (Emory University Hospital)

  • Barbara C. Jobst

    (Dartmouth-Hitchcock Medical Center)

  • Mark A. Gorenstein

    (Dartmouth-Hitchcock Medical Center)

  • Kathryn A. Davis

    (Hospital of the University of Pennsylvania)

  • Gregory A. Worrell

    (Mayo Clinic)

  • Michal T. Kucewicz

    (Mayo Clinic)

  • Joel M. Stein

    (Hospital of the University of Pennsylvania)

  • Richard Gorniak

    (Thomas Jefferson University Hospital)

  • Sandhitsu R. Das

    (Hospital of the University of Pennsylvania)

  • Daniel S. Rizzuto

    (University of Pennsylvania)

  • Michael J. Kahana

    (University of Pennsylvania)

Abstract

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

Suggested Citation

  • Youssef Ezzyat & Paul A. Wanda & Deborah F. Levy & Allison Kadel & Ada Aka & Isaac Pedisich & Michael R. Sperling & Ashwini D. Sharan & Bradley C. Lega & Alexis Burks & Robert E. Gross & Cory S. Inman, 2018. "Closed-loop stimulation of temporal cortex rescues functional networks and improves memory," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02753-0
    DOI: 10.1038/s41467-017-02753-0
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    Cited by:

    1. Denis Demin & Liliya Poskotinova, 2022. "Neurophysiologic Reactions during Heart Rate Variability Biofeedback Session in Adolescents with Different Risk of Internet Addiction," IJERPH, MDPI, vol. 19(5), pages 1-9, February.
    2. Yuxuan Li & Jesse K. Pazdera & Michael J. Kahana, 2024. "EEG decoders track memory dynamics," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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