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Sialic acid-dependent cell entry of human enterovirus D68

Author

Listed:
  • Yue Liu

    (Hockmeyer Hall of Structural Biology, 240 South Martin Jischke Drive, Purdue University)

  • Ju Sheng

    (Hockmeyer Hall of Structural Biology, 240 South Martin Jischke Drive, Purdue University)

  • Jim Baggen

    (Faculty of Veterinary Medicine, Utrecht University)

  • Geng Meng

    (Hockmeyer Hall of Structural Biology, 240 South Martin Jischke Drive, Purdue University)

  • Chuan Xiao

    (University of Texas at El Paso, 500 W. University Avenue)

  • Hendrik J. Thibaut

    (Faculty of Veterinary Medicine, Utrecht University)

  • Frank J. M. van Kuppeveld

    (Faculty of Veterinary Medicine, Utrecht University)

  • Michael G. Rossmann

    (Hockmeyer Hall of Structural Biology, 240 South Martin Jischke Drive, Purdue University)

Abstract

Human enterovirus D68 (EV-D68) is a causative agent of childhood respiratory diseases and has now emerged as a global public health threat. Nevertheless, knowledge of the tissue tropism and pathogenesis of EV-D68 has been hindered by a lack of studies on the receptor-mediated EV-D68 entry into host cells. Here we demonstrate that cell surface sialic acid is essential for EV-D68 to bind to and infect susceptible cells. Crystal structures of EV-D68 in complex with sialylated glycan receptor analogues show that they bind into the ‘canyon’ on the virus surface. The sialic acid receptor induces a cascade of conformational changes in the virus to eject a fatty-acid-like molecule that regulates the stability of the virus. Thus, virus binding to a sialic acid receptor and to immunoglobulin-like receptors used by most other enteroviruses share a conserved mechanism for priming viral uncoating and facilitating cell entry.

Suggested Citation

  • Yue Liu & Ju Sheng & Jim Baggen & Geng Meng & Chuan Xiao & Hendrik J. Thibaut & Frank J. M. van Kuppeveld & Michael G. Rossmann, 2015. "Sialic acid-dependent cell entry of human enterovirus D68," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9865
    DOI: 10.1038/ncomms9865
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    Cited by:

    1. Huixin Li & Yanpeng Xu & Yang Wang & Yihao Cui & Jiake Lin & Yuemin Zhou & Shuling Tang & Ying Zhang & Haibin Hao & Zihao Nie & Xiaoyu Wang & Ruikang Tang, 2023. "Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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