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Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses

Author

Listed:
  • Huixin Li

    (Zhejiang University
    Zhejiang University
    Zhejiang University
    Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province)

  • Yanpeng Xu

    (Capital Institute of Pediatrics)

  • Yang Wang

    (Nantong University)

  • Yihao Cui

    (Zhejiang University)

  • Jiake Lin

    (Zhejiang University)

  • Yuemin Zhou

    (Zhejiang University)

  • Shuling Tang

    (Zhejiang University)

  • Ying Zhang

    (Zhejiang University
    Zhejiang University
    Zhejiang University
    Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province)

  • Haibin Hao

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Zihao Nie

    (Zhejiang University
    Zhejiang University
    Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province)

  • Xiaoyu Wang

    (Zhejiang University
    Zhejiang University
    Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province)

  • Ruikang Tang

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

Abstract

Material-based tactics have attracted extensive attention in driving the functional evolution of organisms. In aiming to design steerable bioartificial organisms to scavenge pathogenic waterborne viruses, we engineer Paramecium caudatum (Para), single-celled microorganisms, with a semiartificial and specific virus-scavenging organelle (VSO). Fe3O4 magnetic nanoparticles modified with a virus-capture antibody (MNPs@Ab) are integrated into the vacuoles of Para during feeding to produce VSOs, which persist inside Para without impairing their swimming ability. Compared with natural Para, which has no capture specificity and shows inefficient inactivation, the VSO-engineered Para (E-Para) specifically gathers waterborne viruses and confines them inside the VSOs, where the captured viruses are completely deactivated because the peroxidase-like nano-Fe3O4 produces virus-killing hydroxyl radicals (•OH) within acidic environment of VSO. After treatment, magnetized E-Para is readily recycled and reused, avoiding further contamination. Materials-based artificial organelles convert natural Para into a living virus scavenger, facilitating waterborne virus clearance without extra energy consumption.

Suggested Citation

  • Huixin Li & Yanpeng Xu & Yang Wang & Yihao Cui & Jiake Lin & Yuemin Zhou & Shuling Tang & Ying Zhang & Haibin Hao & Zihao Nie & Xiaoyu Wang & Ruikang Tang, 2023. "Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40397-5
    DOI: 10.1038/s41467-023-40397-5
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    References listed on IDEAS

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    1. Yue Liu & Ju Sheng & Jim Baggen & Geng Meng & Chuan Xiao & Hendrik J. Thibaut & Frank J. M. van Kuppeveld & Michael G. Rossmann, 2015. "Sialic acid-dependent cell entry of human enterovirus D68," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
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