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Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection

Author

Listed:
  • Yvonne C. F. Su

    (Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School)

  • Justin Bahl

    (Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
    Human Genetics and Environmental Sciences, School of Public Health, The University of Texas)

  • Udayan Joseph

    (Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School)

  • Ka Man Butt

    (Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School)

  • Heidi A. Peck

    (World Health Organisation Collaborating Centre for Reference and Research on Influenza)

  • Evelyn S. C. Koay

    (Molecular Diagnosis Centre, National University Hospital)

  • Lynette L. E. Oon

    (Singapore General Hospital)

  • Ian G. Barr

    (World Health Organisation Collaborating Centre for Reference and Research on Influenza)

  • Dhanasekaran Vijaykrishna

    (Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
    World Health Organisation Collaborating Centre for Reference and Research on Influenza
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Gavin J. D. Smith

    (Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
    World Health Organisation Collaborating Centre for Reference and Research on Influenza
    Duke Global Health Institute, Duke University)

Abstract

Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014.

Suggested Citation

  • Yvonne C. F. Su & Justin Bahl & Udayan Joseph & Ka Man Butt & Heidi A. Peck & Evelyn S. C. Koay & Lynette L. E. Oon & Ian G. Barr & Dhanasekaran Vijaykrishna & Gavin J. D. Smith, 2015. "Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8952
    DOI: 10.1038/ncomms8952
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