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Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis

Author

Listed:
  • Shintaro Aibara

    (R&D)

  • Astrid Kassner

    (Heart and Diabetes Center NRW)

  • Edmond Wong

    (R&D
    AstraZeneca)

  • Karin Klingel

    (University Hospital Tübingen,Liebermeisterstr. 8)

  • Monika Papworth

    (AstraZeneca)

  • Magnus Althage

    (AstraZeneca)

  • Qing-Dong Wang

    (AstraZeneca)

  • Claudia Correia

    (AstraZeneca)

  • Hendrik Milting

    (Heart and Diabetes Center NRW)

  • Taiana Maia de Oliveira

    (R&D)

Abstract

Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient’s heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.

Suggested Citation

  • Shintaro Aibara & Astrid Kassner & Edmond Wong & Karin Klingel & Monika Papworth & Magnus Althage & Qing-Dong Wang & Claudia Correia & Hendrik Milting & Taiana Maia de Oliveira, 2025. "Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis," Nature Communications, Nature, vol. 16(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64902-0
    DOI: 10.1038/s41467-025-64902-0
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    References listed on IDEAS

    as
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