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An eNOS-like nanomaterial for specific reversal of cerebral ischemia-reperfusion injury

Author

Listed:
  • Shuya Wang

    (Central South University
    Central South University)

  • Yuting Xiang

    (Central South University)

  • Xiaojing Shi

    (Central South University)

  • Tingli Xiong

    (Central South University)

  • Ruishi Li

    (Central South University)

  • Wenxuan Zheng

    (Central South University)

  • Wensheng Chen

    (Central South University
    Central South University)

  • Qiaohui Chen

    (Central South University)

  • Yongqi Yang

    (Central South University)

  • Jue Wang

    (Central South University)

  • Qiong Huang

    (Central South University
    Central South University)

  • Kelong Ai

    (Central South University
    Central South University
    Central South University)

Abstract

The protective role of NO has been widely verified in cerebrovascular diseases. However, the beneficial effects of NO depend on its concentration and reactive oxygen species (ROS) level, which makes current NO donors face great difficulties in treating cerebral ischemia-reperfusion injury (CIRI). Here, a tailored MoS2-based NO donor (MSNO) was constructed with defect-rich MoS2, in which the abundant S edge sites in the defects form -SNO, and the Mo sites can also bind NO to form Mo-NO. Combined with MSNO’s own strong ability to eliminate ROS, MSNO could provide pure NO at suitable concentrations like eNOS and avoid the generation of highly toxic ONOO-. After intravenous injection, MSNO with suitable nano-size could penetrate the blood-brain barrier of ischemia-reperfusion injured brain tissue, and effectively treat CIRI through multiple effects: inhibiting calcium overload, alleviating mitochondrial damage and endoplasmic reticulum stress, and inhibiting the inflammatory storm.

Suggested Citation

  • Shuya Wang & Yuting Xiang & Xiaojing Shi & Tingli Xiong & Ruishi Li & Wenxuan Zheng & Wensheng Chen & Qiaohui Chen & Yongqi Yang & Jue Wang & Qiong Huang & Kelong Ai, 2025. "An eNOS-like nanomaterial for specific reversal of cerebral ischemia-reperfusion injury," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64518-4
    DOI: 10.1038/s41467-025-64518-4
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    References listed on IDEAS

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    1. Minrui Fan & Jinru Zhang & Chen-Wei Tsai & Benjamin J. Orlando & Madison Rodriguez & Yan Xu & Maofu Liao & Ming-Feng Tsai & Liang Feng, 2020. "Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex," Nature, Nature, vol. 582(7810), pages 129-133, June.
    2. Nicola B. Hamilton & Karolina Kolodziejczyk & Eleni Kougioumtzidou & David Attwell, 2016. "Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia," Nature, Nature, vol. 529(7587), pages 523-527, January.
    3. Hongyuan Zhang & Zhiqiang Zhao & Shengnan Sun & Sen Zhang & Yuequan Wang & Xuanbo Zhang & Jin Sun & Zhonggui He & Shenwu Zhang & Cong Luo, 2023. "Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Nandhitha Uma Naresh & Cole M. Haynes, 2021. "Breaks in mitochondrial DNA rig the immune response," Nature, Nature, vol. 591(7850), pages 372-373, March.
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