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Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice

Author

Listed:
  • Xianggui Yin

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Changfen Bi

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Yuanfang Chen

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Xueyin Hu

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Guangyou Shi

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Shuqin Li

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Wen Zhang

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Longbo Ma

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Saijun Fan

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Luntao Liu

    (Chinese Academy of Medical Sciences & Peking Union Medical College)

Abstract

Radiation enteritis, affecting over 90% of pelvic/abdominal radiotherapy patients, is primarily caused by radiation-induced reactive oxygen and nitrogen species (RONS). Active hydrogens, with broad-spectrum RONS scavenging ability, show radioprotective potential but face delivery challenges due to the intestinal mucus barrier and short lifespan. Here, we show drinkable, self-thermophoretic sodium alginate/chitosan oligosaccharide-coated hydrogenated molybdenum oxide nanomachines (HxMoO3@SA@COSs) that exhibit near-infrared (NIR)-driven directional motility and sustained active hydrogen release. In a male mouse model of radiation enteritis, HxMoO3@SA@COSs overcome the mucus barrier, prolong intestinal retention, and deliver active hydrogen to injury sites, enabling precise enteritis therapy. Beyond RONS scavenging, the released hydrogen induces anti-inflammatory macrophage polarization, increases goblet cell abundance, and modulates gut microbiota, promoting intestinal repair. This hydrogen-based, drug-free strategy demonstrates superior efficacy in treating radiation enteritis.

Suggested Citation

  • Xianggui Yin & Changfen Bi & Yuanfang Chen & Xueyin Hu & Guangyou Shi & Shuqin Li & Wen Zhang & Longbo Ma & Saijun Fan & Luntao Liu, 2025. "Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice," Nature Communications, Nature, vol. 16(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64270-9
    DOI: 10.1038/s41467-025-64270-9
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