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Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms

Author

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  • Zhiwen Liu

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Kangli Guo

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Liemei Yan

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Kai Zhang

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Ying Wang

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Xiaokang Ding

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Nana Zhao

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

  • Fu-Jian Xu

    (Beijing University of Chemical Technology
    Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education
    Beijing University of Chemical Technology)

Abstract

Safe and efficient antibacterial materials are urgently needed to combat drug-resistant bacteria and biofilm-associated infections. The rational design of nanoparticles for flexible elimination of biofilms remains challenging. Herein, we propose the fabrication of Janus-structured nanoparticles targeting extracellular polymeric substance to achieve dispersion or near-infrared (NIR) light-activated photothermal elimination of drug-resistant biofilms, respectively. Asymmetrical Janus-structured dextran-bismuth selenide (Dex-BSe) nanoparticles are fabricated to exploit synergistic effects of both components. Interestingly, Janus Dex-BSe nanoparticles realize enhanced dispersal of biofilms over time. Alternatively, taking advantage of the preferential accumulation of nanoparticles at infection sites, the self-propelled active motion induced by the unique Janus structure enhances photothermal killing effect. The flexible application of Janus Dex-BSe nanoparticles for biofilm removal or NIR-triggered eradication in vivo is demonstrated by Staphylococcus aureus-infected mouse excisional wound model and abscess model, respectively. The developed Janus nanoplatform holds great promise for the efficient elimination of drug-resistant biofilms in diverse antibacterial scenarios.

Suggested Citation

  • Zhiwen Liu & Kangli Guo & Liemei Yan & Kai Zhang & Ying Wang & Xiaokang Ding & Nana Zhao & Fu-Jian Xu, 2023. "Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40830-9
    DOI: 10.1038/s41467-023-40830-9
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    References listed on IDEAS

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    1. Eric D. Brown & Gerard D. Wright, 2016. "Antibacterial drug discovery in the resistance era," Nature, Nature, vol. 529(7586), pages 336-343, January.
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