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Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance

Author

Listed:
  • Longshun Li

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

  • Aniya Hartzler

    (Case Western Reserve University)

  • Dhariyat M. Menendez-Lustri

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

  • Jichu Zhang

    (Case Western Reserve University)

  • Alex Chen

    (Case Western Reserve University)

  • Danny V. Lam

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

  • Baylee Traylor

    (Haima Therapeutics LLC)

  • Emma Quill

    (Haima Therapeutics LLC)

  • David E. Nethery

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

  • George F. Hoeferlin

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

  • Christa L. Pawlowski

    (Haima Therapeutics LLC)

  • Michael A. Bruckman

    (Haima Therapeutics LLC)

  • Anirban Sen Gupta

    (Case Western Reserve University)

  • Jeffrey R. Capadona

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

  • Andrew J. Shoffstall

    (Case Western Reserve University
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center)

Abstract

Long-term robust intracortical microelectrode (IME) neural recording quality is negatively affected by the neuroinflammatory response following microelectrode insertion. This adversely impacts brain-machine interface (BMI) performance for patients with neurological disorders or amputations. Recent studies suggest that the leakage of blood-brain barrier (BBB) and microhemorrhage caused by IME insertions contribute to increased neuroinflammation and reduced neural recording performance. Here, we evaluated dexamethasone sodium phosphate-loaded platelet-inspired nanoparticles (DEXSPPIN) to simultaneously augment local hemostasis and serve as an implant-site targeted drug-delivery vehicle. Weekly systemic treatment or control therapy was provided to rats for 8 weeks following IME implantation, while evaluating extracellular single-unit recording performance. End-point immunohistochemistry was performed to further assess the local tissue response to the IMEs. Treatment with DEXSPPIN significantly increased the recording capabilities of IMEs compared to controls over the 8-week observation period. Immunohistochemical analyses of neuron density, activated microglia/macrophage density, astrocyte density, and BBB permeability suggested that the improved neural recording performance may be attributed to reduced neuron degeneration and neuroinflammation. Overall, we found that DEXSPPIN treatment promoted an anti-inflammatory environment that improved neuronal density and enhanced IME recording performance.

Suggested Citation

  • Longshun Li & Aniya Hartzler & Dhariyat M. Menendez-Lustri & Jichu Zhang & Alex Chen & Danny V. Lam & Baylee Traylor & Emma Quill & David E. Nethery & George F. Hoeferlin & Christa L. Pawlowski & Mich, 2025. "Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63583-z
    DOI: 10.1038/s41467-025-63583-z
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    References listed on IDEAS

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    1. Leigh R. Hochberg & Mijail D. Serruya & Gerhard M. Friehs & Jon A. Mukand & Maryam Saleh & Abraham H. Caplan & Almut Branner & David Chen & Richard D. Penn & John P. Donoghue, 2006. "Neuronal ensemble control of prosthetic devices by a human with tetraplegia," Nature, Nature, vol. 442(7099), pages 164-171, July.
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