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Generative emergence of non-local representations in the hippocampus

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  • Yuchen Zhou

    (Yale School of Medicine)

  • Jeremie Sibille

    (Yale School of Medicine)

  • George Dragoi

    (Yale School of Medicine
    Yale School of Medicine
    Yale University)

Abstract

The role of internally-generated network dynamics in rapid temporal sequence coding, updating, and parallel recalling of alternate spatial and mental navigation contexts has remained unclear. Here, we revealed rapid emergence of temporally-compressed hippocampal theta sequences in adult male rats within 1-2 laps of a novel detour via re-purposing of pre-existing correlated neuronal sequence motifs expressed during pre-detour sleep. Detour experience-induced neuronal remapping and plasticity were consolidated and reconfigured hippocampal network during post-detour sleep, which predicted future representational drift expressed during the following post-detour reversal-track runs. Pre-detour or reversal-track representations flickered with detour representation across distinct phases of theta oscillation, revealing segregation of non-local internally-generated/recalled and local experience-related hippocampal representations by theta phase. These findings demonstrate that internal generative network dynamics across brain states support rapid theta-scale sequential coding, within-day representational updating, and flickering parallel representations — collectively forming non-local representations — during navigation.

Suggested Citation

  • Yuchen Zhou & Jeremie Sibille & George Dragoi, 2025. "Generative emergence of non-local representations in the hippocampus," Nature Communications, Nature, vol. 16(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63346-w
    DOI: 10.1038/s41467-025-63346-w
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