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Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk

Author

Listed:
  • Zuyou Wu

    (Wuhan University)

  • Yang Yang

    (Huazhong University of Science and Technology)

  • Caibo Ning

    (Wuhan University)

  • Jiali Li

    (Huazhong University of Science and Technology)

  • Yimin Cai

    (Wuhan University)

  • Yanmin Li

    (Wuhan University)

  • Zilong Cao

    (Wuhan University)

  • Shuangshuang Tian

    (Wuhan University)

  • Jingyi Peng

    (Wuhan University)

  • Qianying Ma

    (Wuhan University)

  • Chunyi He

    (Wuhan University)

  • Shuting Xia

    (Wuhan University)

  • Jun Chen

    (Bayer Healthcare)

  • Xiaoping Miao

    (Wuhan University)

  • Zhen Li

    (Huazhong University of Science and Technology)

  • Ying Zhu

    (Wuhan University)

  • Qian Chu

    (Huazhong University of Science and Technology)

  • Jianbo Tian

    (Wuhan University)

Abstract

Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. To identify its underlying genetic factors, we utilized a deep learning algorithm capable of quantifying bone marrow fat fraction (BMFF) in the vertebrae and proximal femur using magnetic resonance imaging data of over 38,000 UK Biobank participants. Genome-wide association analyses uncovered 373 significant BMFF-associated variants (P-value

Suggested Citation

  • Zuyou Wu & Yang Yang & Caibo Ning & Jiali Li & Yimin Cai & Yanmin Li & Zilong Cao & Shuangshuang Tian & Jingyi Peng & Qianying Ma & Chunyi He & Shuting Xia & Jun Chen & Xiaoping Miao & Zhen Li & Ying , 2025. "Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62826-3
    DOI: 10.1038/s41467-025-62826-3
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