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A genetically tractable non-vertebrate system to study complete camera-type eye regeneration

Author

Listed:
  • Alice Accorsi

    (Stowers Institute for Medical Research
    University of California)

  • Brenda Pardo

    (Stowers Institute for Medical Research
    Duke University)

  • Eric Ross

    (Stowers Institute for Medical Research)

  • Timothy J. Corbin

    (Stowers Institute for Medical Research)

  • Melainia McClain

    (Stowers Institute for Medical Research)

  • Kyle Weaver

    (Stowers Institute for Medical Research)

  • Kym Delventhal

    (Stowers Institute for Medical Research
    HHMI Janelia Research Campus)

  • Asmita Gattamraju

    (University of California)

  • Jason A. Morrison

    (Stowers Institute for Medical Research)

  • Mary Cathleen McKinney

    (Stowers Institute for Medical Research)

  • Sean A. McKinney

    (Stowers Institute for Medical Research)

  • Alejandro Sánchez Alvarado

    (Stowers Institute for Medical Research
    Howard Hughes Medical Institute)

Abstract

Camera-type eyes are complex sensory organs susceptible to irreversible damage. Their repair is difficult to study due to the paucity of camera-type eye regeneration models. Identifying a genetically tractable organism with the ability to fully regenerate complete camera-type eyes would help overcome this difficulty. Here, we introduce the apple snail Pomacea canaliculata, capable of full regeneration of camera-type eyes even after complete resection. We defined anatomical components of P. canaliculata eyes and genes expressed during crucial steps of their regeneration. By exploiting the unique features of this organism, we successfully established stable mutant lines in apple snails. Our studies reveal that, akin to humans, pax6 is indispensable for eye development in apple snails, establishing this as a research organism to unravel the mechanisms of camera-type eye regeneration. This work expands our understanding of complex sensory organ regeneration and offers a way to explore this process.

Suggested Citation

  • Alice Accorsi & Brenda Pardo & Eric Ross & Timothy J. Corbin & Melainia McClain & Kyle Weaver & Kym Delventhal & Asmita Gattamraju & Jason A. Morrison & Mary Cathleen McKinney & Sean A. McKinney & Ale, 2025. "A genetically tractable non-vertebrate system to study complete camera-type eye regeneration," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61681-6
    DOI: 10.1038/s41467-025-61681-6
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    References listed on IDEAS

    as
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    3. Aissam Ikmi & Sean A. McKinney & Kym M. Delventhal & Matthew C. Gibson, 2014. "TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    4. Cristina Grande & Nipam H. Patel, 2009. "Nodal signalling is involved in left–right asymmetry in snails," Nature, Nature, vol. 457(7232), pages 1007-1011, February.
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