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Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications

Author

Listed:
  • Zhou Gao

    (Sun Yat-sen University)

  • Christopher Rensing

    (Fujian Agriculture and Forestry University)

  • Jie Wang

    (Fujian Agriculture and Forestry University)

  • Chenhui Shen

    (Oil Crops Research Institute of Chinese Academy of Agricultural Science)

  • Mohammed Esmail Abdalla Elzaki

    (Fujian Agriculture and Forestry University)

  • Xiaoyun Li

    (Sun Yat-sen University)

  • Jinfang Tan

    (Sun Yat-sen University)

  • Xiaoqian Jiang

    (Sun Yat-sen University)

Abstract

RNA interference is an eco-friendly alternative to chemical pesticides, yet its efficacy in lepidopterans like Spodoptera frugiperda (S. frugiperda) is limited by poor uptake. Here, we report on ZIF-8 polydopamine nanoparticles that protect dsRNA against enzymatic degradation and active the endocytic/phagosome pathways for increased uptake. Furthermore, the uptake of nano-enabled dsRNA induces the overgrowth of Serratia marcescens, this reduces the S. frugiperda reactive oxygen species (ROS) immune response, increasing the effects of plant’s natural defenses, further inhibiting Enteroccous mundtii growth. This work shows the synergistic potential of nanoparticles for influencing the gut bacteria to prevent resistance mechanisms and for RNAi delivery for pest management.

Suggested Citation

  • Zhou Gao & Christopher Rensing & Jie Wang & Chenhui Shen & Mohammed Esmail Abdalla Elzaki & Xiaoyun Li & Jinfang Tan & Xiaoqian Jiang, 2025. "Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61604-5
    DOI: 10.1038/s41467-025-61604-5
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    References listed on IDEAS

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    1. Yuxi Wang & Mingshan Li & Jiahan Ying & Jie Shen & Daolong Dou & Meizhen Yin & Stephen C. Whisson & Paul R. J. Birch & Shuo Yan & Xiaodan Wang, 2023. "High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Gunter Meister & Thomas Tuschl, 2004. "Mechanisms of gene silencing by double-stranded RNA," Nature, Nature, vol. 431(7006), pages 343-349, September.
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