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A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Author

Listed:
  • Xingcan Huang

    (City University of Hong Kong)

  • Qiang Zhang

    (City University of Hong Kong
    City University of Hong Kong)

  • Yawen Yang

    (City University of Hong Kong)

  • Lung Chow

    (City University of Hong Kong)

  • Jie Ma

    (The Hong Kong Polytechnic University)

  • Guoqiang Xu

    (City University of Hong Kong)

  • Fang Guo

    (The University of Hong Kong
    The Hong Kong Polytechnic University)

  • Xinxin He

    (City University of Hong Kong)

  • Zhiyuan Li

    (City University of Hong Kong)

  • Guangyao Zhao

    (City University of Hong Kong)

  • Jingyou Su

    (Hong Kong Baptist University)

  • Guihuan Guo

    (City University of Hong Kong)

  • Jiachen Wang

    (City University of Hong Kong)

  • Yanli Jiao

    (City University of Hong Kong
    New Territories)

  • Zhan Gao

    (City University of Hong Kong)

  • Jiyu Li

    (City University of Hong Kong
    Shenzhen Campus of Sun Yat-sen University)

  • Jingkun Zhou

    (City University of Hong Kong
    New Territories)

  • Chun Ki Yiu

    (City University of Hong Kong
    New Territories)

  • Jian Li

    (City University of Hong Kong
    New Territories)

  • Yi Chen

    (Sichuan University
    Sichuan University
    Nursing Key Laboratory of Sichuan Province)

  • Pengcheng Wu

    (City University of Hong Kong)

  • Kuanming Yao

    (City University of Hong Kong)

  • Yiming Liu

    (City University of Hong Kong
    Macau University of Science and Technology)

  • Dengfeng Li

    (City University of Hong Kong)

  • Binbin Zhang

    (City University of Hong Kong
    New Territories)

  • Hongwei Chu

    (City University of Hong Kong)

  • Yue Hu

    (City University of Hong Kong
    Shenzhen University)

  • Ya Huang

    (City University of Hong Kong
    Fudan University)

  • Zhenlin Chen

    (City University of Hong Kong
    New Territories)

  • Kangning Ren

    (Hong Kong Baptist University)

  • Bo Fang

    (The Hong Kong Polytechnic University
    The Hong Kong Polytechnic University)

  • Rungong Yang

    (The first medical center of Chinese PLA General Hospital)

  • Heng Li

    (The Hong Kong Polytechnic University
    The Hong Kong Polytechnic University)

  • Xiaoming Tao

    (The Hong Kong Polytechnic University
    The Hong Kong Polytechnic University)

  • Xiaohui Ma

    (The first medical center of Chinese PLA General Hospital)

  • Xinge Yu

    (City University of Hong Kong
    City University of Hong Kong
    New Territories
    City University of Hong Kong)

Abstract

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.

Suggested Citation

  • Xingcan Huang & Qiang Zhang & Yawen Yang & Lung Chow & Jie Ma & Guoqiang Xu & Fang Guo & Xinxin He & Zhiyuan Li & Guangyao Zhao & Jingyou Su & Guihuan Guo & Jiachen Wang & Yanli Jiao & Zhan Gao & Jiyu, 2025. "A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61261-8
    DOI: 10.1038/s41467-025-61261-8
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