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Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging

Author

Listed:
  • Ye Yang

    (Peking University
    Peking University)

  • Binlong Chen

    (Peking University
    Peking University)

  • Fangjie Wan

    (Peking University
    Peking University)

  • Chuanxun Fu

    (Peking University
    Peking University)

  • Meifang Chen

    (Peking University
    Peking University)

  • Bin Ma

    (Peking University
    Peking University)

  • Ruiyang Zhao

    (Peking University
    Peking University)

  • Meijie Pan

    (Peking University
    Peking University)

  • Qiang Zhang

    (Peking University
    Peking University)

  • Yiguang Wang

    (Peking University
    Peking University
    Peking University)

Abstract

The pH in organisms is strictly regulated within an appropriate range for homeostasis, and many pathological processes often result in pH dysregulation to distinct intervals that serves as targets for diagnosis and treatment. Thus, a mechanism of selective and gating response for different proton levels in an integrated nanodevice is needed to report acidic biological environments with specific pH dynamic ranges. Here we report the design of band-pass light-up nanokits (BLINK) with pH heterogating capacity in opposite directions to achieve selective reporting of the acidic intervals (minimum to 0.25 pH unit) of pathophysiological environments. The proton heterogated property of BLINK integrates ultra-fast (

Suggested Citation

  • Ye Yang & Binlong Chen & Fangjie Wan & Chuanxun Fu & Meifang Chen & Bin Ma & Ruiyang Zhao & Meijie Pan & Qiang Zhang & Yiguang Wang, 2025. "Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61255-6
    DOI: 10.1038/s41467-025-61255-6
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