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Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging

Author

Listed:
  • Ye Yang

    (Peking University
    Peking University)

  • Binlong Chen

    (Peking University
    Peking University)

  • Fangjie Wan

    (Peking University
    Peking University)

  • Chuanxun Fu

    (Peking University
    Peking University)

  • Meifang Chen

    (Peking University
    Peking University)

  • Bin Ma

    (Peking University
    Peking University)

  • Ruiyang Zhao

    (Peking University
    Peking University)

  • Meijie Pan

    (Peking University
    Peking University)

  • Qiang Zhang

    (Peking University
    Peking University)

  • Yiguang Wang

    (Peking University
    Peking University
    Peking University)

Abstract

The pH in organisms is strictly regulated within an appropriate range for homeostasis, and many pathological processes often result in pH dysregulation to distinct intervals that serves as targets for diagnosis and treatment. Thus, a mechanism of selective and gating response for different proton levels in an integrated nanodevice is needed to report acidic biological environments with specific pH dynamic ranges. Here we report the design of band-pass light-up nanokits (BLINK) with pH heterogating capacity in opposite directions to achieve selective reporting of the acidic intervals (minimum to 0.25 pH unit) of pathophysiological environments. The proton heterogated property of BLINK integrates ultra-fast (

Suggested Citation

  • Ye Yang & Binlong Chen & Fangjie Wan & Chuanxun Fu & Meifang Chen & Bin Ma & Ruiyang Zhao & Meijie Pan & Qiang Zhang & Yiguang Wang, 2025. "Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61255-6
    DOI: 10.1038/s41467-025-61255-6
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    References listed on IDEAS

    as
    1. Ferdia A. Gallagher & Mikko I. Kettunen & Sam E. Day & De-En Hu & Jan Henrik Ardenkjær-Larsen & René in ‘t Zandt & Pernille R. Jensen & Magnus Karlsson & Klaes Golman & Mathilde H. Lerche & Kevin M. B, 2008. "Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate," Nature, Nature, vol. 453(7197), pages 940-943, June.
    2. Anyuan Liu & Xiaoshuai Huang & Wenting He & Fudong Xue & Yanrui Yang & Jiajia Liu & Liangyi Chen & Lin Yuan & Pingyong Xu, 2021. "pHmScarlet is a pH-sensitive red fluorescent protein to monitor exocytosis docking and fusion steps," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Yang Li & Tian Zhao & Chensu Wang & Zhiqiang Lin & Gang Huang & Baran D. Sumer & Jinming Gao, 2016. "Molecular basis of cooperativity in pH-triggered supramolecular self-assembly," Nature Communications, Nature, vol. 7(1), pages 1-11, December.
    4. Martin Grashei & Pascal Wodtke & Jason G. Skinner & Sandra Sühnel & Nadine Setzer & Thomas Metzler & Sebastian Gulde & Mihyun Park & Daniela Witt & Hermine Mohr & Christian Hundshammer & Nicole Stritt, 2023. "Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Stephan Düwel & Christian Hundshammer & Malte Gersch & Benedikt Feuerecker & Katja Steiger & Achim Buck & Axel Walch & Axel Haase & Steffen J. Glaser & Markus Schwaiger & Franz Schilling, 2017. "Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
    6. Yanjun Zhang & Yasufumi Takahashi & Sung Pil Hong & Fengjie Liu & Joanna Bednarska & Philip S. Goff & Pavel Novak & Andrew Shevchuk & Sahana Gopal & Iros Barozzi & Luca Magnani & Hideki Sakai & Yoshim, 2019. "High-resolution label-free 3D mapping of extracellular pH of single living cells," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
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